UTP22 rRNA-processing protein UTP22 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: UTP22
Official Full Name: rRNA-processing protein UTP22
Primary source: SGD:S000003322
Locus tag: YGR090W
See related: AllianceGenome:SGD:S000003322; FungiDB:YGR090W; VEuPathDB:YGR090W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable RNA binding activity. Involved in rRNA processing and tRNA export from nucleus. Located in nucleolus. Part of CURI complex; UTP-C complex; and small-subunit processome. Orthologous to human NOL6 (nucleolar protein 6). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

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A dynamic Ifh1-Utp22 interaction fine-tunes ribosomal protein gene (RPG) expression to coordinate RPG and rRNA transcription.
Title: A Molecular Titration System Coordinates Ribosomal Protein Gene Transcription with Ribosomal RNA Synthesis.
data suggest that Utp22p recruits Utp8p to aminoacyl-tRNA synthetases in the nucleolus to collect aminoacyl-tRNA
Title: Utp22p acts in concert with Utp8p to channel aminoacyl-tRNA from the nucleolus to the nuclear tRNA export receptor Los1p but not Msn5p.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info
involved_in tRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of 90S preribosome	HDA more info	PubMed
part_of CURI complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CURI complex	IDA Inferred from Direct Assay more info	PubMed
part_of UTP-C complex	IBA Inferred from Biological aspect of Ancestor more info
part_of UTP-C complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	HDA more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	IDA Inferred from Direct Assay more info	PubMed

NP_011604.3

Component of the small-subunit processome; required for nuclear export of tRNAs; forms a complex with Rrp7p; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals

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