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    VIR1 Vir1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852847, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VIR1
    Official Full Name
    Vir1p
    Primary source
    SGD:S000003004
    Locus tag
    YGL036W
    See related
    AllianceGenome:SGD:S000003004; FungiDB:YGL036W; VEuPathDB:YGL036W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in meiotic cell cycle. Located in cytoplasm. Part of RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VIR1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (428601..431330)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene initiation-specific alpha-1,6-mannosyltransferase Neighboring gene nicotinamidase Neighboring gene transcription factor MIG1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles. Ensinck I, et al. Elife, 2023 Jul 25. PMID 37490041, Free PMC Article
    2. Kar4, the yeast homolog of METTL14, is required for mRNA m6A methylation and meiosis. Park ZM, et al. PLoS Genet, 2023 Aug. PMID 37603553, Free PMC Article
    3. Vir1p, the yeast homolog of virilizer, is required for mRNA m6A methylation and meiosis. Park ZM, et al. Genetics, 2023 May 4. PMID 36930734, Free PMC Article
    4. The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae. Josefson R, et al. Sci Rep, 2023 Jun 7. PMID 37286562, Free PMC Article
    5. The ubiquitin-proteasome system regulates meiotic chromosome organization. Yang X, et al. Proc Natl Acad Sci U S A, 2022 Apr 26. PMID 35439061, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of RNA N6-methyladenosine methyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Vir1p
    NP_011479.1
    • Protein required for mRNA m6A methylation and meiosis; subunit of the m6A methyltransferase (MIS) complex; required for the stability of MIS complex subunits and consistent with a scaffolding function; non-essential gene required for pre-meiotic S-phase; may be required to initiate the meiotic program, for progression through meiotic divisions and for spore formation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of VIRMA/virilizer/VIR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      428601..431330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180901.1 → NP_011479.1  TPA: Vir1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011479.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUA3, P53185
      UniProtKB/TrEMBL
      B3LIP7, N1P3A0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53185.1

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