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    EAF1 Eaf1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851962, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EAF1
    Official Full Name
    Eaf1p
    Primary source
    SGD:S000002767
    Locus tag
    YDR359C
    See related
    AllianceGenome:SGD:S000002767; FungiDB:YDR359C; VEuPathDB:YDR359C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    VID21
    Summary
    Predicted to enable chromatin binding activity. Involved in DNA repair and protein-containing complex assembly. Part of NuA4 histone acetyltransferase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EAF1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1191936..1194884, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Cnl1p Neighboring gene ubiquitin-binding protein Neighboring gene protein-transporting protein BCP1 Neighboring gene transcription factor TFIIIC subunit TFC6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. eaf1Delta mutant decreases expression level of genes implicated in the purine biosynthesis.
      Title: Eaf1 Links the NuA4 Histone Acetyltransferase Complex to Htz1 Incorporation and Regulation of Purine Biosynthesis.
    2. the deletion of EAF1 causes the collapse of the NuA4 complex and displays 148 genetic interactions. Eaf1 plays a crucial function in NuA4 complex integrity.
      Title: Functional dissection of the NuA4 histone acetyltransferase reveals its role as a genetic hub and that Eaf1 is essential for complex integrity.
    3. Eaf1 is the only subunit exclusively found in the NuA4 complex. It is the center, making distinct physical interactions with 4 different functional modules, assembling the native NuA4 complex.
      Title: Eaf1 is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NuA4 histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Eaf1p
    NP_010646.4
    • Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1191936..1194884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180667.3 → NP_010646.4  TPA: Eaf1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010646.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSY8, Q06337, Q6S6F6
      UniProtKB/TrEMBL
      B3LFU3, C8Z5S1, N1P794
      Conserved Domains (2) summary
      smart00573
      Location:347 → 418
      HSA; domain in helicases and associated with SANT domains
      pfam13921
      Location:650 → 700
      Myb_DNA-bind_6; Myb-like DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06337.2

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