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    CNL1 Cnl1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851959, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CNL1
    Official Full Name
    Cnl1p
    Primary source
    SGD:S000002765
    Locus tag
    YDR357C
    See related
    AllianceGenome:SGD:S000002765; FungiDB:YDR357C; VEuPathDB:YDR357C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in endosome organization and regulation of protein localization. Located in cytoplasm. Part of BLOC-1 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CNL1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1189199..1189567, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene anthranilate phosphoribosyltransferase Neighboring gene Spc110p Neighboring gene ubiquitin-binding protein Neighboring gene Eaf1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae. Norambuena L, et al. BMC Chem Biol, 2008 Jan 7. PMID 18179719, Free PMC Article
    2. Yeast homologues of three BLOC-1 subunits highlight KxDL proteins as conserved interactors of BLOC-1. Hayes MJ, et al. Traffic, 2011 Mar. PMID 21159114, Free PMC Article
    3. The BLOC-1 complex promotes endosomal maturation by recruiting the Rab5 GTPase-activating protein Msb3. John Peter AT, et al. J Cell Biol, 2013 Apr 1. PMID 23547030, Free PMC Article
    4. Identification of a Rab GTPase-activating protein cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole. Rana M, et al. Mol Biol Cell, 2015 Jul 1. PMID 25971802, Free PMC Article
    5. RNAi expression tuning, microfluidic screening, and genome recombineering for improved protein production in Saccharomyces cerevisiae. Wang G, et al. Proc Natl Acad Sci U S A, 2019 May 7. PMID 31000602, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BLOC-1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BLOC-1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of BLOC-1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of BLOC-1 complex ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cnl1p
    NP_010644.1
    • Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1189199..1189567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180665.1 → NP_010644.1  TPA: Cnl1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010644.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZYV6, B3LFU5, C7GMH9, C8Z5R9, D6VSY6, E7KB73, E7NG53, E7QDA1, Q06333
      UniProtKB/TrEMBL
      N1P5C4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06333.1

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