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    HXT3 hexose transporter HXT3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851946, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HXT3
    Official Full Name
    hexose transporter HXT3
    Primary source
    SGD:S000002753
    Locus tag
    YDR345C
    See related
    AllianceGenome:SGD:S000002753; FungiDB:YDR345C; VEuPathDB:YDR345C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables D-glucose transmembrane transporter activity. Involved in D-glucose transmembrane transport. Located in plasma membrane. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HXT3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1162957..1164660, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene hexose transporter HXT6 Neighboring gene uncharacterized protein Neighboring gene Svf1p Neighboring gene mitochondrial 37S ribosomal protein MRP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Engineering of an endogenous hexose transporter into a specific D-xylose transporter facilitates glucose-xylose co-consumption in Saccharomyces cerevisiae. Nijland JG, et al. Biotechnol Biofuels, 2014. PMID 25505932, Free PMC Article
    2. Specificity and regulation of DNA binding by the yeast glucose transporter gene repressor Rgt1. Kim JH, et al. Mol Cell Biol, 2003 Aug. PMID 12861007, Free PMC Article
    3. Downshifting Yeast Dominance: Cell Physiology and Phospholipid Composition Are Altered With Establishment of the [GAR (+)] Prion in Saccharomyces cerevisiae. Walker GA, et al. Front Microbiol, 2020. PMID 32983023, Free PMC Article
    4. Modeling simultaneous glucose and xylose uptake in Saccharomyces cerevisiae from kinetics and gene expression of sugar transporters. Bertilsson M, et al. Bioprocess Biosyst Eng, 2008 Jun. PMID 17985160
    5. Reduction of glucose uptake through inhibition of hexose transporters and enhancement of their endocytosis by methylglyoxal in Saccharomyces cerevisiae. Yoshida A, et al. J Biol Chem, 2012 Jan 2. PMID 22094464, Free PMC Article

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. turnover of both Hxt3 and Hxt7 is dependent on the essential E3 ubiquitin ligase, Rsp5, indicating that the role of the Vid30c might be indirect of Hxt ubiquitylation
      Title: Regulation of Hxt3 and Hxt7 turnover converges on the Vid30 complex and requires inactivation of the Ras/cAMP/PKA pathway in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbohydrate:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mannose transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in carbohydrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hexose transmembrane transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mannose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hexose transporter HXT3
    NP_010632.1
    • Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1162957..1164660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180653.1 → NP_010632.1  TPA: hexose transporter HXT3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010632.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSX5, P32466
      UniProtKB/TrEMBL
      A6ZYU5, B3LFV5, E9P9G8, N1P8P4
      Conserved Domains (1) summary
      pfam00083
      Location:65 → 525
      Sugar_tr; Sugar (and other) transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32466.1

    Gene LinkOut

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