SWR1 chromatin-remodeling protein SWR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SWR1
Official Full Name: chromatin-remodeling protein SWR1
Primary source: SGD:S000002742
Locus tag: YDR334W
See related: AllianceGenome:SGD:S000002742; FungiDB:YDR334W; VEuPathDB:YDR334W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables structural molecule activity. Involved in chromatin remodeling and recombinational repair. Located in cytosol and nucleus. Part of Swr1 complex. Human ortholog(s) of this gene implicated in Floating-Harbor syndrome. Orthologous to human SRCAP (Snf2 related CREBBP activator protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SWR1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1135932..1140476)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stabilization of the hexasome intermediate during histone exchange by yeast SWR1 complex.
Title: Stabilization of the hexasome intermediate during histone exchange by yeast SWR1 complex.
What makes a histone variant a variant: Changing H2A to become H2A.Z.
Title: What makes a histone variant a variant: Changing H2A to become H2A.Z.
Swc4 positively regulates telomere length independently of its roles in NuA4 and SWR1 complexes.
Title: Swc4 positively regulates telomere length independently of its roles in NuA4 and SWR1 complexes.
Swr1 localization to its targets is dependent on H2A.Z during directional transcription in Saccharomyces cerevisiae.
Title: The histone variant H2A.Z in yeast is almost exclusively incorporated into the +1 nucleosome in the direction of transcription.
Findings show the molecular basis for the recognition of H3K27ac by a YEATS reader, and the importance of this interaction in mediating Yaf9 function within the NuA4 histone acetyltransferase complex catalytic subunit (NuA4) and chromatin-remodeling protein SWR1 (SWR1) complexes.
Title: Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain.
Functional characterization and architecture of recombinant yeast SWR1 histone exchange complex has been reported.
Title: Functional characterization and architecture of recombinant yeast SWR1 histone exchange complex.
The authors found that SWR1 primarily recognizes key residues within the alpha2 helix in the histone-fold of nucleosomal histone H2A, a region not previously known to influence remodeler activity.
Title: H2A histone-fold and DNA elements in nucleosome activate SWR1-mediated H2A.Z replacement in budding yeast.
Incorporation of histone H2A.Z (Htz1) variant by SWR-C (Swr1) remodeling enzyme may stimulate Exo1 activity, as well as enhance the fidelity of replication by Pol delta, the repair of mismatches generated by Pol delta, or both.
Title: Deposition of histone H2A.Z by the SWR-C remodeling enzyme prevents genome instability.
the cooperative heterochromatin regulation of Asf1 and SWR1
Title: Maintenance of heterochromatin boundary and nucleosome composition at promoters by the Asf1 histone chaperone and SWR1-C chromatin remodeler in Saccharomyces cerevisiae.
The Swr1-Z domain can deliver the H2A.Z-H2B dimer to the DNA-(H3-H4)2 tetrasome to form the nucleosome by a histone chaperone mechanism.
Title: The catalytic subunit of the SWR1 remodeler is a histone chaperone for the H2A.Z-H2B dimer.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables forked DNA-dependent helicase activity	IEA Inferred from Electronic Annotation more info
enables four-way junction helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables single-stranded 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables structural molecule activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in recombinational repair	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Swr1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Swr1 complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chromatin-remodeling protein SWR1

NP_010621.1

EC 3.6.4.12

Swi2/Snf2-related ATPase; catalytic subunit of SWR1 complex, which exchanges histone variant H2A.Z (Htz1p) for chromatin-bound histone H2A; N-terminus can deliver H2A.Z-H2B dimer to DNA-(H3-H4)2 tetrasome; relocalizes to cytosol in response to hypoxia; chronological aging factor, mediates lifespan extension by dietary restriction

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1135932..1140476

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180642.1 → NP_010621.1 TPA: chromatin-remodeling protein SWR1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010621.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSW6, Q05471

UniProtKB/TrEMBL

A6ZYT6, B3LFW3

Conserved Domains (3) summary

COG0553
Location:659 → 1413

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd18003
Location:696 → 932

DEXQc_SRCAP; DEXH/Q-box helicase domain of SRCAP

cl02676
Location:340 → 393

HSA