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    MET32 Met32p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851840, updated on 9-Dec-2024

    Summary

    Official Symbol
    MET32
    Official Full Name
    Met32p
    Primary source
    SGD:S000002661
    Locus tag
    YDR253C
    See related
    AllianceGenome:SGD:S000002661; FungiDB:YDR253C; VEuPathDB:YDR253C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of mitotic cell cycle; regulation of sulfur amino acid metabolic process; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See MET32 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (963990..964565, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pam1p Neighboring gene CCR4-NOT core subunit BTT1 Neighboring gene Chl4p Neighboring gene ubiquitin-protein ligase RMD5

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Met32p
    NP_010539.1
    • Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; feedforward loop exists in the regulation of genes controlled by Met4p and Met32p; lack of such a loop for MET31 may account for the differential actions of Met32p and Met31p; MET32 has a paralog, MET31, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      963990..964565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180561.1NP_010539.1  TPA: Met32p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010539.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSN3, Q12041
      UniProtKB/TrEMBL
      A6ZYK5, B3LG37, B5VGD7, C7GTI8, C8Z5G5, G2WAZ6, N1P531
      Conserved Domains (2) summary
      COG5048
      Location:41191
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:100120
      ZF_C2H2; C2H2 Zn finger [structural motif]