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    SSY1 Ssy1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851738, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SSY1
    Official Full Name
    Ssy1p
    Primary source
    SGD:S000002567
    Locus tag
    YDR160W
    See related
    AllianceGenome:SGD:S000002567; FungiDB:YDR160W; VEuPathDB:YDR160W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RAA1; SHR10
    Summary
    Predicted to enable amino acid transmembrane transporter activity. Involved in response to amino acid. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SSY1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (776163..778721)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene aspartate-semialdehyde dehydrogenase Neighboring gene Sac3p Neighboring gene Acl4p Neighboring gene Nbp2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Competitive intra- and extracellular nutrient sensing by the transporter homologue Ssy1p. Wu B, et al. J Cell Biol, 2006 May 8. PMID 16651382, Free PMC Article
    2. Cascading transcriptional effects of a naturally occurring frameshift mutation in Saccharomyces cerevisiae. Brown KM, et al. Mol Ecol, 2008 Jun. PMID 18422925
    3. Mutations in Saccharomyces cerevisiae which confer resistance to several amino acid analogs. McCusker JH, et al. Mol Cell Biol, 1990 Jun. PMID 2188104, Free PMC Article
    4. Hyper- and hyporesponsive mutant forms of the Saccharomyces cerevisiae Ssy1 amino acid sensor. Poulsen P, et al. Mol Membr Biol, 2008 Feb. PMID 18307103
    5. Intrinsically disordered linker and plasma membrane-binding motif sort Ist2 and Ssy1 to junctions. Kralt A, et al. Traffic, 2015 Feb. PMID 25409870

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hypersensitive SSY1 mutations negatively influence transition to quiescence in yeast Saccharomyces cerevisiae.
      Title: Hypersensitive SSY1 mutations negatively influence transition to quiescence in yeast Saccharomyces cerevisiae.
    2. The Saccharomyces cerevisiae Ssy5 signaling protease (SSY5) is a core component of the plasma membrane (PM)-localized Ssy1-Ptr3-Ssy5 (SPS) sensor.
      Title: Spatial and temporal regulation of the endoproteolytic activity of the SPS-sensor-controlled Ssy5 signaling protease.
    3. C-terminal of Ssy1 carries a functional ER-export motif required for proper localization of Ssy1 to the plasma membrane. Ssy1 functions as the primary amino acid receptor and that it carries out this function at the PM.
      Title: Ssy1 functions at the plasma membrane as a receptor of extracellular amino acids independent of plasma membrane-endoplasmic reticulum junctions.
    4. Ssy1 localization depends on the presence of a PM-binding domain, an intrinsically disordered linker region of sufficient length.
      Title: Intrinsically disordered linker and plasma membrane-binding motif sort Ist2 and Ssy1 to junctions.
    5. Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae.
      Title: Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae.
    6. Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway.
      Title: Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway.
    7. SSY1 mutants that constitutively activate a target promoter, were isolated.
      Title: Hyper- and hyporesponsive mutant forms of the Saccharomyces cerevisiae Ssy1 amino acid sensor.
    8. Data confirm that a frameshift mutation in a mononucleotide run of eight consecutive T's in the coding region SSY1 causes dramatic differences in gene-expression levels of key genes involved in amino acid biosynthesis.
      Title: Cascading transcriptional effects of a naturally occurring frameshift mutation in Saccharomyces cerevisiae.
    9. SSY1, a tranporter-like sensor, allows the cell to respond to changes in nutrient availability through detection of the relative concentrations of intra- and extracellular ligand.
      Title: Competitive intra- and extracellular nutrient sensing by the transporter homologue Ssy1p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to amino acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ssy1p
    NP_010444.1
    • Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      776163..778721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180467.1 → NP_010444.1  TPA: Ssy1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010444.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSE0, Q03770
      UniProtKB/TrEMBL
      B3LGC4, C7GX40
      Conserved Domains (1) summary
      TIGR00913
      Location:278 → 819
      2A0310; amino acid permease (yeast)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03770.1

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