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    GAL7 UDP-glucose:hexose-1-phosphate uridylyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852306, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GAL7
    Official Full Name
    UDP-glucose:hexose-1-phosphate uridylyltransferase
    Primary source
    SGD:S000000222
    Locus tag
    YBR018C
    See related
    AllianceGenome:SGD:S000000222; FungiDB:YBR018C; VEuPathDB:YBR018C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity. Involved in galactose catabolic process via UDP-galactose. Located in cytoplasm. Used to study galactosemia. Human ortholog(s) of this gene implicated in classic galactosemia and galactosemia. Orthologous to human GALT (galactose-1-phosphate uridylyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GAL7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (274427..275527, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene cysteine-rich palmitoylated domain-containing protein CPP1 Neighboring gene Kap104p Neighboring gene ncRNA Neighboring gene bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase Neighboring gene galactokinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Primary structure of the Saccharomyces cerevisiae GAL7 gene. Tajima M, et al. Yeast, 1985 Sep. PMID 2851900
    2. Subcellular localization of galactose-1-phosphate uridylyltransferase in the yeast Saccharomyces cerevisiae. Christacos NC, et al. Mol Genet Metab, 2000 Aug. PMID 10993714
    3. Allelic variation, aneuploidy, and nongenetic mechanisms suppress a monogenic trait in yeast. Sirr A, et al. Genetics, 2015 Jan. PMID 25398792, Free PMC Article
    4. Functional consequence of substitutions at residue 171 in human galactose-1-phosphate uridylyltransferase. Crews C, et al. J Biol Chem, 2000 Jul 28. PMID 10811638
    5. The enzymes of the galactose cluster in Saccharomyces cerevisiae. Purification and characterization of galactose-1-phosphate uridylyltransferase. Segawa T, et al. J Biol Chem, 1979 Nov 10. PMID 387754

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. quantitative relationship between galactokinase activity, gal-1P accumulation, and growth arrest of galactose-challenged GALT or GALE-deficiency
      Title: Distinct roles of galactose-1P in galactose-mediated growth arrest of yeast deficient in galactose-1P uridylyltransferase (GALT) and UDP-galactose 4'-epimerase (GALE).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in galactose catabolic process via UDP-galactose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in galactose catabolic process via UDP-galactose IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in galactose catabolic process via UDP-galactose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in galactose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-glucose:hexose-1-phosphate uridylyltransferase
    NP_009574.1
    • Galactose-1-phosphate uridyl transferase; synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism; human homolog UGP2 can complement yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      274427..275527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178366.1 → NP_009574.1  TPA: UDP-glucose:hexose-1-phosphate uridylyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009574.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ20, P04398, P08431
      UniProtKB/TrEMBL
      A6ZKW4, B5VDY7, C7GM34, G2W925, N1P6E1
      Conserved Domains (1) summary
      TIGR00209
      Location:3 → 366
      galT_1; galactose-1-phosphate uridylyltransferase, family 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08431.4

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