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    PTH2 aminoacyl-tRNA hydrolase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852223, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PTH2
    Official Full Name
    aminoacyl-tRNA hydrolase
    Primary source
    SGD:S000000153
    Locus tag
    YBL057C
    See related
    AllianceGenome:SGD:S000000153; FungiDB:YBL057C; VEuPathDB:YBL057C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables aminoacyl-tRNA hydrolase activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in mitochondrial outer membrane. Orthologous to human PTRH2 (peptidyl-tRNA hydrolase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PTH2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (112801..113427, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Iai11p Neighboring gene protein phosphatase regulator SHP1 Neighboring gene type 2C protein phosphatase PTC3 Neighboring gene 3'-5'-exodeoxyribonuclease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enzymatic hydrolysis of N-substituted aminoacyl transfer ribonucleic acid in yeast. Jost JP, et al. J Biol Chem, 1969 Nov 10. PMID 4981785
    2. Peptidyl-tRNA hydrolase from Sulfolobus solfataricus. Fromant M, et al. Nucleic Acids Res, 2003 Jun 15. PMID 12799450, Free PMC Article
    3. Yeast Irc22 Is a Novel Dsk2-Interacting Protein that Is Involved in Salt Tolerance. Ishii T, et al. Cells, 2014 Mar 27. PMID 24709957, Free PMC Article
    4. Sequencing and functional analysis of a 32,560 bp segment on the left arm of yeast chromosome II. Identification of 26 open reading frames, including the KIP1 and SEC17 genes. Scherens B, et al. Yeast, 1993 Dec. PMID 8154187
    5. Yeast Pth2 is a UBL domain-binding protein that participates in the ubiquitin-proteasome pathway. Ishii T, et al. EMBO J, 2006 Nov 29. PMID 17082762, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that Pth2 negatively regulates the UBL-UBA protein-mediated shuttling pathway in the ubiquitin-proteasome system.
      Title: Yeast Pth2 is a UBL domain-binding protein that participates in the ubiquitin-proteasome pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aminoacyl-tRNA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminoacyl-tRNA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aminoacyl-tRNA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA hydrolase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    aminoacyl-tRNA hydrolase
    NP_009496.2
    • One of two mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth; see also PTH1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      112801..113427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178297.2 → NP_009496.2  TPA: aminoacyl-tRNA hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009496.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPU3, P34222
      UniProtKB/TrEMBL
      A6ZKP2, B5VDS8, C8Z3P1, G2W8V2
      Conserved Domains (1) summary
      TIGR00283
      Location:88 → 208
      arch_pth2; peptidyl-tRNA hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34222.2

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