SCT1 bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SCT1
Official Full Name: bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1
Primary source: SGD:S000000107
Locus tag: YBL011W
See related: AllianceGenome:SGD:S000000107; FungiDB:YBL011W; VEuPathDB:YBL011W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GAT2
Summary: Enables glycerol-3-phosphate O-acyltransferase activity and glycerone-phosphate O-acyltransferase activity. Involved in phospholipid biosynthetic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SCT1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (203538..205817)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

novel mechanism for the regulation of fatty acid desaturation that is based on competition between Ole1p and the glycerol-3-phosphate acyltransferase Sct1p/Gat2p for the common substrate C16:0-CoA
Title: The yeast acyltransferase Sct1p regulates fatty acid desaturation by competing with the desaturase Ole1p.
Gat1 and Gat2 localized to both perinuclear and cortical endoplasmic reticula in actively proliferating cells.
Title: Glycerol-3-phosphate acyltransferases gat1p and gat2p are microsomal phosphoproteins with differential contributions to polarized cell growth.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol-3-phosphate O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerol-3-phosphate O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate O-acyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycerone-phosphate O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerone-phosphate O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerone-phosphate O-acyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CDP-diacylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1

NP_009542.1

EC 2.3.1.15

EC 2.3.1.42

Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; dual substrate-specific acyltransferase of the glycerolipid biosynthesis pathway; prefers 16-carbon fatty acids; similar to Gpt2p; gene is constitutively transcribed

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

203538..205817

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178251.1 → NP_009542.1 TPA: bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009542.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPY8, P32784, Q07062, Q96TV1

UniProtKB/TrEMBL

G2W8Z7

Conserved Domains (2) summary

cd07992
Location:56 → 343

LPLAT_AAK14816-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like

pfam17158
Location:441 → 548

MASE4; Membrane-associated sensor, integral membrane domain