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    CYC3 holocytochrome c synthase CYC3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851192, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CYC3
    Official Full Name
    holocytochrome c synthase CYC3
    Primary source
    SGD:S000000037
    Locus tag
    YAL039C
    See related
    AllianceGenome:SGD:S000000037; FungiDB:YAL039C; VEuPathDB:YAL039C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables holocytochrome-c synthase activity. Involved in cytochrome c-heme linkage. Located in mitochondrial intermembrane space. Used to study microphthalmia. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 1 and microphthalmia. Orthologous to human HCCS (holocytochrome c synthase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CYC3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (68716..69525, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Rho family guanine nucleotide exchange factor CDC24 Neighboring gene cyclin CLN3 Neighboring gene pyruvate kinase CDC19 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of cytochrome c heme lyase in mitochondrial import and accumulation of cytochrome c in Saccharomyces cerevisiae. Dumont ME, et al. Mol Cell Biol, 1991 Nov. PMID 1656231, Free PMC Article
    2. Identification and sequence of the gene encoding cytochrome c heme lyase in the yeast Saccharomyces cerevisiae. Dumont ME, et al. EMBO J, 1987 Jan. PMID 3034577, Free PMC Article
    3. Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation and characterization of the CDC24 gene and adjacent regions of the chromosome. Coleman KG, et al. Mol Cell Biol, 1986 Dec. PMID 3540615, Free PMC Article
    4. Formation of a cytochrome c-like species from horse apoprotein and hemin catalyzed by yeast mitochondrial cytochrome c synthetase. Veloso D, et al. J Biol Chem, 1981 Aug 25. PMID 6267048
    5. Evidence for formation of two thioether bonds to link heme to apocytochrome c by partially purified cytochrome c synthetase. Taniuchi H, et al. J Biol Chem, 1983 Sep 25. PMID 6309825

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. in vivo, Cyc2p interacts with cytochrome c heme lyase and is involved in the reduction of heme prior to its ligation to apocytochrome c by CCHL
      Title: Cyc2p, a membrane-bound flavoprotein involved in the maturation of mitochondrial c-type cytochromes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables holocytochrome-c synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables holocytochrome-c synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables holocytochrome-c synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytochrome c-heme linkage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    holocytochrome c synthase CYC3
    NP_009361.1
    • Cytochrome c heme lyase (holocytochrome c synthase); attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in mitochondrial intermembrane space; human homolog HCCS implicated in microphthalmia with linear skin defects (MLS), and can complement yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      68716..69525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178184.1 → NP_009361.1  TPA: holocytochrome c synthase CYC3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009361.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPH7, P06182
      UniProtKB/TrEMBL
      A7A0C7, B3LUX5, C7GPJ8, C8Z3F0, G2W8J1, N1P9S6
      Conserved Domains (1) summary
      pfam01265
      Location:1 → 253
      Cyto_heme_lyase; Cytochrome c/c1 heme lyase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06182.1

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