Ccn3 cellular communication network factor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccn3provided by MGI
Official Full Name: cellular communication network factor 3provided by MGI
Primary source: MGI:MGI:109185
See related: Ensembl:ENSMUSG00000037362 AllianceGenome:MGI:109185
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nov; C130088N23Rik
Summary: Enables hormone activity. Involved in several processes, including bone regeneration; negative regulation of insulin secretion; and type B pancreatic cell proliferation. Acts upstream of with a positive effect on negative regulation of SMAD protein signal transduction. Located in extracellular region. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human CCN3 (cellular communication network factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in colon adult (RPKM 83.7), frontal lobe adult (RPKM 20.9) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 21.49 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (54609306..54617158)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (54745910..54753762)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A maternal brain hormone that builds bone.
Title: A maternal brain hormone that builds bone.
CCN3/NOV Regulates Proliferation and Neuronal Differentiation in Mouse Hippocampal Neural Stem Cells via the Activation of the Notch/PTEN/AKT Pathway.
Title: CCN3/NOV Regulates Proliferation and Neuronal Differentiation in Mouse Hippocampal Neural Stem Cells via the Activation of the Notch/PTEN/AKT Pathway.
The matricellular protein CCN3 supports lung endothelial homeostasis and function.
Title: The matricellular protein CCN3 supports lung endothelial homeostasis and function.
Myeloid CCN3 protects against aortic valve calcification.
Title: Myeloid CCN3 protects against aortic valve calcification.
Silencing the Adipocytokine NOV: A Novel Approach to Reversing Oxidative Stress-Induced Cardiometabolic Dysfunction.
Title: Silencing the Adipocytokine NOV: A Novel Approach to Reversing Oxidative Stress-Induced Cardiometabolic Dysfunction.
Elevated Expression of CCN3 in Articular Cartilage Induces Osteoarthritis in Hip Joints Irrespective of Age and Weight Bearing.
Title: Elevated Expression of CCN3 in Articular Cartilage Induces Osteoarthritis in Hip Joints Irrespective of Age and Weight Bearing.
High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway.
Title: High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway.
CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage.
Title: CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage.
our findings suggested that CCN3 significantly inhibited the osteogenic differentiation of mouse embryonic fibroblasts. The inhibitory effect of CCN3 was mainly through the inhibition of BMP signaling and the mutual inhibition with DLL1, so as to inhibit the expression of Hey1, the target gene shared by BMP and Notch signaling pathways.
Title: CCN3 and DLL1 co-regulate osteogenic differentiation of mouse embryonic fibroblasts in a Hey1-dependent manner.
Taken together, our results suggest that palmitoylation by ZDHHC22 at C241 in the CCN3 TSP1 domain may be required for the secretion of CCN3. Aberrant palmitoylation induces intracellular accumulation of CCN3, inhibiting neuronal axon growth.
Title: CCN3 secretion is regulated by palmitoylation via ZDHHC22.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nov (e-PCR), detects polymorphism
- UniSTS:526865

X96585 (e-PCR)
- UniSTS:180756

Nov (e-PCR), detects polymorphism
- UniSTS:508569

Nov (e-PCR), detects polymorphism
- UniSTS:532681

Nov (e-PCR), detects polymorphism
- UniSTS:507096

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Notch binding	IEA Inferred from Electronic Annotation more info
enables Notch binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in bone regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in chondrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in fibroblast migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in hematopoietic stem cell homeostasis	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic stem cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect negative regulation of SMAD protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chondrocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myotube differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ossification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in type B pancreatic cell proliferation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in gap junction	ISO Inferred from Sequence Orthology more info
located_in gap junction	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CCN family member 3

Names: nephroblastoma overexpressed; nephroblastoma-overexpressed gene protein homolog; novH; protein NOV homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010930.5 → NP_035060.1 CCN family member 3 precursor

See identical proteins and their annotated locations for NP_035060.1

Status: VALIDATED

Source sequence(s)

AC129583

Consensus CDS

CCDS27471.1

UniProtKB/Swiss-Prot

Q64299, Q8CA67

UniProtKB/TrEMBL

Q3U2X7

Related

ENSMUSP00000054389.9, ENSMUST00000050027.9

Conserved Domains (3) summary

smart00121
Location:28 → 89

IB; Insulin growth factor-binding protein homologues

smart00041
Location:266 → 335

CT; C-terminal cystine knot-like domain (CTCK)

smart00214
Location:104 → 164

VWC; von Willebrand factor (vWF) type C domain