Grap GRB2-related adaptor protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grapprovided by MGI
Official Full Name: GRB2-related adaptor proteinprovided by MGI
Primary source: MGI:MGI:1918770
See related: Ensembl:ENSMUSG00000004837 AllianceGenome:MGI:1918770
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 8430435N19Rik
Summary: Predicted to enable epidermal growth factor receptor binding activity and phosphotyrosine residue binding activity. Predicted to be involved in regulation of MAPK cascade; sensory perception of sound; and signal transduction. Predicted to be located in presynapse. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm; nucleoplasm; and plasma membrane. Is expressed in cochlea; liver; lung; metanephros; and nervous system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 114. Orthologous to several human genes including GRAP (GRB2 related adaptor protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 43.4), thymus adult (RPKM 39.3) and 14 other tissues See more
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Genomic context

Location:: 11 B2; 11 37.96 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (61544081..61563610)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (61653321..61672777)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Grb2-related adaptor protein GRAP is a novel regulator of liver fibrosis.
Title: Grb2-related adaptor protein GRAP is a novel regulator of liver fibrosis.
Grb2-related adaptor protein (GRAP) was up-regulated in kidney tubules from diabetic mice, indicating a potential novel role for GRAP in TGF-beta-induced tubule injury in diabetic kidney disease.
Title: Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling.
Results suggest that the GRAP gene might have a role in the pathogenesis of Sjogren's syndrome.
Title: Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndrome.
Data suggest that Grap, unlike Grb2, acts as a negative regulator of TCR-stimulated intracellular signaling by downregulating signal relay through the Ras/Erk pathway.
Title: Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction.
FcgammaRIIB docking site for the SH2 domain-containing adapters Grb2 and Grap
Title: Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB233594 (e-PCR)
- UniSTS:185884

BB247706 (e-PCR)
- UniSTS:208691

MARC_4617-4618:966894528:1 (e-PCR)
- UniSTS:269410

NoName (e-PCR)
- UniSTS:491490

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphotyrosine residue binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sound	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: GRB2-related adapter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027817.3 → NP_082093.1 GRB2-related adapter protein

See identical proteins and their annotated locations for NP_082093.1

Status: PROVISIONAL

Source sequence(s)

AL596209

Consensus CDS

CCDS24817.1

UniProtKB/Swiss-Prot

Q0VBE3, Q3U545, Q9CX99

Related

ENSMUSP00000004959.3, ENSMUST00000004959.3

Conserved Domains (3) summary

cd09941
Location:56 → 150

SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins

cd11948
Location:2 → 55

SH3_GRAP_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein

cl17036
Location:162 → 214

SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

61544081..61563610

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156992.1 → XP_036012885.1 GRB2-related adapter protein isoform X1

Conserved Domains (3) summary

cd11948
Location:2 → 55

SH3_GRAP_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein

cl15255
Location:15 → 109

SH2; Src homology 2 (SH2) domain

cl17036
Location:121 → 173

SH3; Src Homology 3 domain superfamily