Mcam melanoma cell adhesion molecule [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mcamprovided by MGI
Official Full Name: melanoma cell adhesion moleculeprovided by MGI
Primary source: MGI:MGI:1933966
See related: Ensembl:ENSMUSG00000032135 AllianceGenome:MGI:1933966
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD146; CD149; Muc18; s-endo; 1-gicerin; s-gicerin
Summary: Predicted to enable laminin receptor activity. Predicted to be involved in angiogenesis and positive regulation of cell migration. Predicted to act upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be located in external side of plasma membrane and extracellular space. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; extraembryonic component; genitourinary system; gut; and nervous system. Orthologous to human MCAM (melanoma cell adhesion molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 97.6), lung adult (RPKM 73.6) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.1; 9 24.68 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (44045958..44054024)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (44134658..44142727)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD146-dependent macrophage infiltration promotes epidural fibrosis via the Erdr1/ERK/CCR2 pathway.
Title: CD146-dependent macrophage infiltration promotes epidural fibrosis via the Erdr1/ERK/CCR2 pathway.
CD146 deficiency aggravates chronic obstructive pulmonary disease via the increased production of S100A9 and MMP-9 in macrophages.
Title: CD146 deficiency aggravates chronic obstructive pulmonary disease via the increased production of S100A9 and MMP-9 in macrophages.
Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling.
Title: Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling.
CD146 deficiency promotes inflammatory type 2 responses in pulmonary cryptococcosis.
Title: CD146 deficiency promotes inflammatory type 2 responses in pulmonary cryptococcosis.
Galphai1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis.
Title: Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis.
Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM.
Title: Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM.
CD146 at the Interface between Oxidative Stress and the Wnt Signaling Pathway in Systemic Sclerosis.
Title: CD146 at the Interface between Oxidative Stress and the Wnt Signaling Pathway in Systemic Sclerosis.
Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/beta-catenin pathway.
Title: Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/β-catenin pathway.
The CD146-HIF-1alpha axis regulates epithelial cell migration and alveolar maturation in a mouse model of bronchopulmonary dysplasia.
Title: The CD146-HIF-1α axis regulates epithelial cell migration and alveolar maturation in a mouse model of bronchopulmonary dysplasia.
Inhibition of CD146 attenuates retinal neovascularization via vascular endothelial growth factor receptor 2 signalling pathway in proliferative diabetic retinopathy.
Title: Inhibition of CD146 attenuates retinal neovascularization via vascular endothelial growth factor receptor 2 signalling pathway in proliferative diabetic retinopathy.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables laminin receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in glomerular filtration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in vascular wound healing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: cell surface glycoprotein MUC18

Names: gicerin; l-gicerin protein; melanoma adhesion molecule; melanoma-associated antigen MUC18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359530.2 → NP_001346459.1 cell surface glycoprotein MUC18 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC148328

Consensus CDS

CCDS90545.1

Related

ENSMUSP00000096451.3, ENSMUST00000098852.3

Conserved Domains (4) summary

pfam08205
Location:141 → 236

C2-set_2; CD80-like C2-set immunoglobulin domain

pfam13927
Location:348 → 412

Ig_3; Immunoglobulin domain

cl11960
Location:34 → 120

Ig; Immunoglobulin domain

cl28434
Location:440 → 517

I-set; Immunoglobulin I-set domain
NM_001421323.1 → NP_001408252.1 cell surface glycoprotein MUC18 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC148328
NM_023061.3 → NP_075548.2 cell surface glycoprotein MUC18 isoform 1 precursor

See identical proteins and their annotated locations for NP_075548.2

Status: VALIDATED

Source sequence(s)

AC148328

Consensus CDS

CCDS23097.1

UniProtKB/Swiss-Prot

Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3

Related

ENSMUSP00000034650.9, ENSMUST00000034650.15

Conserved Domains (5) summary

smart00408
Location:266 → 323

IGc2; Immunoglobulin C-2 Type

smart00410
Location:356 → 424

IG_like; Immunoglobulin like

pfam08205
Location:141 → 236

C2-set_2; CD80-like C2-set immunoglobulin domain

pfam13895
Location:351 → 427

Ig_2; Immunoglobulin domain

cl11960
Location:452 → 509

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

44045958..44054024

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244742.2 → XP_030100602.1 cell surface glycoprotein MUC18 isoform X2

Conserved Domains (4) summary

smart00409
Location:242 → 310

IG; Immunoglobulin

pfam08205
Location:27 → 122

C2-set_2; CD80-like C2-set immunoglobulin domain

pfam13927
Location:142 → 209

Ig_3; Immunoglobulin domain

cl11960
Location:326 → 403

Ig; Immunoglobulin domain
XM_030244743.2 → XP_030100603.1 cell surface glycoprotein MUC18 isoform X3

Conserved Domains (4) summary

smart00409
Location:242 → 310

IG; Immunoglobulin

pfam08205
Location:27 → 122

C2-set_2; CD80-like C2-set immunoglobulin domain

pfam13927
Location:142 → 209

Ig_3; Immunoglobulin domain

cl11960
Location:326 → 403

Ig; Immunoglobulin domain