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    Dcc DCC netrin 1 receptor [ Mus musculus (house mouse) ]

    Gene ID: 13176, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dccprovided by MGI
    Official Full Name
    DCC netrin 1 receptorprovided by MGI
    Primary source
    MGI:MGI:94869
    See related
    Ensembl:ENSMUSG00000060534 AllianceGenome:MGI:94869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Igdcc1; C030036D22Rik
    Summary
    Predicted to enable identical protein binding activity; netrin receptor activity; and transcription coactivator activity. Involved in postsynaptic modulation of chemical synaptic transmission. Acts upstream of or within generation of neurons. Located in axon. Is active in Schaffer collateral - CA1 synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and retina. Used to study essential thrombocythemia and polycythemia vera. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 7.6), CNS E14 (RPKM 7.4) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dcc in Genome Data Viewer
    Location:
    18 E2; 18 45.24 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (71386703..72484299, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (71253613..72351228, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene lysosomal-associated protein transmembrane 4B pseudogene Neighboring gene ribosomal protein S6 kinase, polypeptide 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44969 Neighboring gene STARR-seq mESC enhancer starr_44970 Neighboring gene STARR-seq mESC enhancer starr_44971 Neighboring gene STARR-seq mESC enhancer starr_44972 Neighboring gene STARR-seq mESC enhancer starr_44973 Neighboring gene STARR-seq mESC enhancer starr_44974 Neighboring gene STARR-seq mESC enhancer starr_44975 Neighboring gene STARR-seq mESC enhancer starr_44976 Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44977 Neighboring gene STARR-seq mESC enhancer starr_44978 Neighboring gene predicted gene, 31819

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables netrin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in growth cone membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density membrane IEP
    Inferred from Expression Pattern
    more info
    PubMed 

    General protein information

    Preferred Names
    netrin receptor DCC
    Names
    deleted in colorectal carcinoma
    tumor suppressor protein DCC

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007831.3NP_031857.2  netrin receptor DCC precursor

      See identical proteins and their annotated locations for NP_031857.2

      Status: VALIDATED

      Source sequence(s)
      AC136637, AK090377, AK157715, BQ550935, CN665025
      Consensus CDS
      CCDS29336.1
      UniProtKB/Swiss-Prot
      G3X9X6, P70211
      Related
      ENSMUSP00000110593.4, ENSMUST00000114943.11
      Conserved Domains (8) summary
      smart00408
      Location:153219
      IGc2; Immunoglobulin C-2 Type
      smart00060
      Location:726805
      FN3; Fibronectin type 3 domain
      cd00063
      Location:528617
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06583
      Location:11481445
      Neogenin_C; Neogenin C-terminus
      pfam07679
      Location:241327
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:246251
      Ig; Ig strand A' [structural motif]
      cd05722
      Location:39136
      IgI_1_Neogenin_like; First immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05723
      Location:334417
      IgI_4_Neogenin_like; Fourth immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      71386703..72484299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525588.5XP_006525651.1  netrin receptor DCC isoform X1

      UniProtKB/Swiss-Prot
      P70211
      Related
      ENSMUSP00000073094.6, ENSMUST00000073379.6
      Conserved Domains (7) summary
      cd05722
      Location:42136
      Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
      smart00408
      Location:153219
      IGc2; Immunoglobulin C-2 Type
      smart00060
      Location:726805
      FN3; Fibronectin type 3 domain
      cd00063
      Location:528617
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06583
      Location:11281425
      Neogenin_C; Neogenin C-terminus
      pfam07679
      Location:241327
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:347417
      Ig; Immunoglobulin domain