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    Adamts8 ADAM metallopeptidase with thrombospondin type 1 motif 8 [ Mus musculus (house mouse) ]

    Gene ID: 30806, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adamts8provided by MGI
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif 8provided by MGI
    Primary source
    MGI:MGI:1353468
    See related
    Ensembl:ENSMUSG00000031994 AllianceGenome:MGI:1353468
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    METH2; METH-2
    Summary
    This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. This gene is expressed in mouse lung, heart and macrophage-rich areas of atherosclerotic plaques. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent aggrecanase enzyme. This gene is located adjacent to a related ADAMTS gene on chromosome 9. [provided by RefSeq, May 2016]
    Expression
    Broad expression in lung adult (RPKM 4.1), limb E14.5 (RPKM 1.2) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adamts8 in Genome Data Viewer
    Location:
    9 A4; 9 16.49 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (30853858..30875134)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (30942562..30963838)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23671 Neighboring gene STARR-seq mESC enhancer starr_23672 Neighboring gene predicted gene, 31140 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 15 Neighboring gene predicted gene, 29724 Neighboring gene STARR-seq mESC enhancer starr_23676 Neighboring gene STARR-seq mESC enhancer starr_23679 Neighboring gene STARR-positive B cell enhancer ABC_E6719 Neighboring gene STARR-seq mESC enhancer starr_23682 Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene STARR-seq mESC enhancer starr_23684 Neighboring gene predicted gene, 17508

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ADAMTS8 Promotes the Development of Pulmonary Arterial Hypertension and Right Ventricular Failure: A Possible Novel Therapeutic Target. Omura J, et al. Circ Res, 2019 Oct 25. PMID 31556812
    2. Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin. Rossier J, et al. Mol Psychiatry, 2015 Feb. PMID 25510509, Free PMC Article
    3. ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. Georgiadis KE, et al. Genomics, 1999 Dec 1. PMID 10610729
    4. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. Vázquez F, et al. J Biol Chem, 1999 Aug 13. PMID 10438512
    5. ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques. Wågsäter D, et al. Atherosclerosis, 2008 Feb. PMID 17606262

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADAMTS8 deletion reduced pulmonary artery smooth muscle cell proliferation with AMPK up-regulation.
      Title: ADAMTS8 Promotes the Development of Pulmonary Arterial Hypertension and Right Ventricular Failure: A Possible Novel Therapeutic Target.
    2. This study demonstrated that Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8 in mice.
      Title: Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin.
    3. ADAMTS-4 expression was upregulated during the development of atherosclerosis in LDLR(-/-)ApoB(100/100) mice.
      Title: ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 8
    Names
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8
    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326292.1 → NP_001313221.1  A disintegrin and metalloproteinase with thrombospondin motifs 8 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK043875, CT025653

    2. NM_013906.3 → NP_038934.2  A disintegrin and metalloproteinase with thrombospondin motifs 8 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_038934.2

      Status: REVIEWED

      Source sequence(s)
      AK043875, CT025653
      Consensus CDS
      CCDS22946.1
      UniProtKB/Swiss-Prot
      P57110
      UniProtKB/TrEMBL
      F8VQ15
      Related
      ENSMUSP00000069644.7, ENSMUST00000068135.13
      Conserved Domains (6) summary
      smart00209
      Location:545 → 597
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:234 → 441
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:234 → 444
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:52 → 152
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:706 → 825
      ADAM_spacer1; ADAM-TS Spacer 1
      cl15456
      Location:463 → 529
      ADAM_CR; ADAM cysteine-rich

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      30853858..30875134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P57110.1 GenPept UniProtKB/Swiss-Prot:P57110

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