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    Ptpn2 protein tyrosine phosphatase, non-receptor type 2 [ Mus musculus (house mouse) ]

    Gene ID: 19255, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptpn2provided by MGI
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 2provided by MGI
    Primary source
    MGI:MGI:97806
    See related
    Ensembl:ENSMUSG00000024539 AllianceGenome:MGI:97806
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ptpt; TC-PTP
    Summary
    Enables STAT family protein binding activity and protein tyrosine phosphatase activity. Involved in several processes, including hemopoiesis; negative regulation of leukocyte differentiation; and regulation of signal transduction. Acts upstream of or within insulin receptor signaling pathway; negative regulation of transcription by RNA polymerase II; and protein dephosphorylation. Located in nucleus. Is active in endosome lumen. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; lower jaw; and midbrain. Orthologous to human PTPN2 (protein tyrosine phosphatase non-receptor type 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.3), CNS E14 (RPKM 3.0) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ptpn2 in Genome Data Viewer
    Location:
    18 E1; 18 40.06 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (67798571..67857697, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (67665501..67724632, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 76 Neighboring gene proteasome (prosome, macropain) assembly chaperone 2 Neighboring gene STARR-positive B cell enhancer ABC_E11000 Neighboring gene STARR-positive B cell enhancer ABC_E8723 Neighboring gene STARR-seq mESC enhancer starr_44912 Neighboring gene predicted gene, 46626 Neighboring gene STARR-positive B cell enhancer ABC_E11001 Neighboring gene predicted gene, 26910 Neighboring gene SEH1-like (S. cerevisiae

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables STAT family protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in insulin receptor recycling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epidermal growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interleukin-2-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interleukin-2-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-4-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interleukin-4-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-6-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interleukin-6-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of macrophage colony-stimulating factor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of macrophage differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of positive thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of type I interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of type II interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of type II interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of type II interferon-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tyrosine phosphorylation of STAT protein ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptidyl-tyrosine dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-tyrosine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of PERK-mediated unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein dephosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of hepatocyte growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of hepatocyte growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endosome lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type 2
    Names
    MPTP
    T cell protein-tyrosine phosphatase
    protein-tyrosine phosphatase PTP-2
    NP_001120649.1
    NP_033003.1
    XP_011245160.1
    XP_011245161.1
    XP_030106224.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127177.1NP_001120649.1  tyrosine-protein phosphatase non-receptor type 2 isoform b

      See identical proteins and their annotated locations for NP_001120649.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript.
      Source sequence(s)
      AC108434, AK014528, AK076072, AK132013, CA560046, DV552728
      Consensus CDS
      CCDS50311.1
      UniProtKB/Swiss-Prot
      Q06180, Q3V259, Q922E7
      UniProtKB/TrEMBL
      D3Z6W2
      Related
      ENSMUSP00000112675.2, ENSMUST00000122412.2
      Conserved Domains (2) summary
      smart00194
      Location:5274
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:45274
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. NM_008977.3NP_033003.1  tyrosine-protein phosphatase non-receptor type 2 isoform a

      See identical proteins and their annotated locations for NP_033003.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 3' UTR and has multiple coding region differences, compared to variant 2. The resulting protein (isoform a) has a distinct C-terminus and is shorter than isoform b.
      Source sequence(s)
      AK014528, AK076072, CA560046, DV552728
      Consensus CDS
      CCDS37851.1
      UniProtKB/TrEMBL
      D3Z6W2
      Related
      ENSMUSP00000025420.8, ENSMUST00000025420.14
      Conserved Domains (1) summary
      cl28904
      Location:19272
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      67798571..67857697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246858.4XP_011245160.1  tyrosine-protein phosphatase non-receptor type 2 isoform X1

      See identical proteins and their annotated locations for XP_011245160.1

      UniProtKB/TrEMBL
      D3Z6W2
      Conserved Domains (1) summary
      cl28904
      Location:19272
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    2. XM_030250364.2XP_030106224.1  tyrosine-protein phosphatase non-receptor type 2 isoform X2

      Conserved Domains (1) summary
      cl28904
      Location:1173
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    3. XM_011246859.1XP_011245161.1  tyrosine-protein phosphatase non-receptor type 2 isoform X2

      See identical proteins and their annotated locations for XP_011245161.1

      Conserved Domains (1) summary
      cl28904
      Location:1173
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily