Tes testin LIM domain protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tesprovided by MGI
Official Full Name: testin LIM domain proteinprovided by MGI
Primary source: MGI:MGI:105081
See related: Ensembl:ENSMUSG00000029552 AllianceGenome:MGI:105081
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TESS; Tes1; Tes2; testin2; D6Ertd352e
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of cell population proliferation. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo mesenchyme; and metanephros. Orthologous to human TES (testin LIM domain protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 40.0), large intestine adult (RPKM 38.6) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A2; 6 7.67 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (17065148..17105824)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (17065149..17105825)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of testin is downregulated in murine hypertrophic hearts.Testin serves as a crucial regulator of the hypertrophic reaction by hindering the calcineurin-dependent pathway in the heart.
Title: Testin protects against cardiac hypertrophy by targeting a calcineurin-dependent signalling pathway.
zyxin influences focal adhesion dynamics, that it recruits Tes and that this interaction is functional in regulating cell spreading.
Title: Delineating the Tes Interaction Site in Zyxin and Studying Cellular Effects of Its Disruption.
Testin is a mammalian gene involved in coordinated orientation of hair cells in the inner ear and in the development of the female reproductive tract.
Title: Testin interacts with vangl2 genetically to regulate inner ear sensory cell orientation and the normal development of the female reproductive tract in mice.
TES acts as a tumor suppressor in an established model of carcinogen-induced gastric cancer
Title: Knockout mice reveal a tumor suppressor function for Testin.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G54122 (e-PCR)
- UniSTS:109359

RH127026 (e-PCR)
- UniSTS:167479

D6Mit347 (e-PCR), detects polymorphism
- UniSTS:130898

Tes (e-PCR), detects polymorphism
- UniSTS:508036

Tes (e-PCR), detects polymorphism
- UniSTS:508037

X78990 (e-PCR)
- UniSTS:125856

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: testin

Names: TES1/TES2; testin 2; testis derived transcript

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207176.3 → NP_997059.1 testin

See identical proteins and their annotated locations for NP_997059.1

Status: VALIDATED

Source sequence(s)

AC159332

Consensus CDS

CCDS39429.1

UniProtKB/TrEMBL

Q3ULB1, Q921B1, Q921W7

Related

ENSMUSP00000111127.5, ENSMUST00000115467.11

Conserved Domains (4) summary

cd09413
Location:234 → 291

LIM1_Testin; The first LIM domain of Testin

cd09416
Location:297 → 352

LIM2_Testin; The second LIM domain of Testin

cd09419
Location:359 → 417

LIM3_Testin; The third LIM domain of Testin

cd09829
Location:109 → 196

PET_testin; The PET domain of Testin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

17065148..17105824

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_011570.3: Suppressed sequence

Description

NM_011570.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.