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    Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N [ Mus musculus (house mouse) ]

    Gene ID: 20716, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Serpina3nprovided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade A, member 3Nprovided by MGI
    Primary source
    MGI:MGI:105045
    See related
    Ensembl:ENSMUSG00000021091 AllianceGenome:MGI:105045
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spi2-2; Spi2.2; Spi2/eb.4
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within response to bacterium; response to cytokine; and response to peptide hormone. Located in extracellular region. Is expressed in nervous system; sensory organ; skeleton; thymus primordium; and urinary system. Human ortholog(s) of this gene implicated in adult respiratory distress syndrome; chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 296.6), liver adult (RPKM 171.8) and 7 other tissues See more
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    Genomic context

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    See Serpina3n in Genome Data Viewer
    Location:
    12 E; 12 54.17 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (104372967..104380588)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (104406646..104414334)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3M Neighboring gene STARR-seq mESC enhancer starr_33137 Neighboring gene predicted gene, 40561 Neighboring gene STARR-seq mESC enhancer starr_33138 Neighboring gene predicted gene, 24334 Neighboring gene STARR-seq mESC enhancer starr_33139 Neighboring gene predicted gene, 40562

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SerpinA3N attenuates ischemic stroke injury by reducing apoptosis and neuroinflammation. Zhang Y, et al. CNS Neurosci Ther, 2022 Apr. PMID 34897996, Free PMC Article
    2. Serpina3n, Dominantly Expressed in Female Osteoblasts, Suppresses the Phenotypes of Differentiated Osteoblasts in Mice. Ishida M, et al. Endocrinology, 2018 Nov 1. PMID 30304388
    3. Muscle NAD(+) depletion and Serpina3n as molecular determinants of murine cancer cachexia-the effects of blocking myostatin and activins. Hulmi JJ, et al. Mol Metab, 2020 Nov. PMID 32599075, Free PMC Article
    4. Serpina3n is closely associated with fibrotic procession and knockdown ameliorates bleomycin-induced pulmonary fibrosis. Gong GC, et al. Biochem Biophys Res Commun, 2020 Nov 19. PMID 32900484
    5. A Potential Role for SerpinA3N in Acetaminophen-Induced Hepatotoxicity. Tran M, et al. Mol Pharmacol, 2021 Apr. PMID 33436521, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Serine protease inhibitor, SerpinA3n, regulates cardiac remodelling after myocardial infarction.
      Title: Serine protease inhibitor, SerpinA3n, regulates cardiac remodelling after myocardial infarction.
    2. SerpinA3N Regulates the Secretory Phenotype of Mouse Senescent Astrocytes Contributing to Neurodegeneration.
      Title: SerpinA3N Regulates the Secretory Phenotype of Mouse Senescent Astrocytes Contributing to Neurodegeneration.
    3. Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-kappaB signaling pathway in mice with temporal lobe epilepsy.
      Title: Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy.
    4. SerpinA3N deficiency attenuates steatosis and enhances insulin signaling in male mice.
      Title: SerpinA3N deficiency attenuates steatosis and enhances insulin signaling in male mice.
    5. Neuronal Serpina3n is an endogenous protector against blood brain barrier damage following cerebral ischemic stroke.
      Title: Neuronal Serpina3n is an endogenous protector against blood brain barrier damage following cerebral ischemic stroke.
    6. Downregulation of Sepina3n Aggravated Blood-Brain Barrier Disruption after Traumatic Brain Injury by Activating Neutrophil Elastase in Mice.
      Title: Downregulation of Sepina3n Aggravated Blood-Brain Barrier Disruption after Traumatic Brain Injury by Activating Neutrophil Elastase in Mice.
    7. Serpin Signatures in Prion and Alzheimer's Diseases.
      Title: Serpin Signatures in Prion and Alzheimer's Diseases.
    8. SerpinA3N attenuates ischemic stroke injury by reducing apoptosis and neuroinflammation.
      Title: SerpinA3N attenuates ischemic stroke injury by reducing apoptosis and neuroinflammation.
    9. Longitudinal Single-Cell Transcriptomics Reveals a Role for Serpina3n-Mediated Resolution of Inflammation in a Mouse Colitis Model.
      Title: Longitudinal Single-Cell Transcriptomics Reveals a Role for Serpina3n-Mediated Resolution of Inflammation in a Mouse Colitis Model.
    10. SerpinA3n affects ovalbumin (OVA)-induced asthma in neonatal mice via the regulation of collagen deposition and inflammatory response.
      Title: SerpinA3n affects ovalbumin (OVA)-induced asthma in neonatal mice via the regulation of collagen deposition and inflammatory response.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acute-phase response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cytokine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to peptide hormone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine protease inhibitor A3N
    Names
    alpha-1 antiproteinase
    antitrypsin
    serine (or cysteine) proteinase inhibitor, clade A, member 3N
    serine protease inhibitor 2-2
    serpin A3N

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009252.2 → NP_033278.2  serine protease inhibitor A3N precursor

      See identical proteins and their annotated locations for NP_033278.2

      Status: VALIDATED

      Source sequence(s)
      AC117194
      Consensus CDS
      CCDS26152.1
      UniProtKB/Swiss-Prot
      Q62258, Q91WP6
      UniProtKB/TrEMBL
      G3X8T9
      Related
      ENSMUSP00000021506.6, ENSMUST00000021506.6
      Conserved Domains (1) summary
      cd19551
      Location:37 → 418
      serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      104372967..104380588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WP6.1 GenPept UniProtKB/Swiss-Prot:Q91WP6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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