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    Wnk2 WNK lysine deficient protein kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 75607, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wnk2provided by MGI
    Official Full Name
    WNK lysine deficient protein kinase 2provided by MGI
    Primary source
    MGI:MGI:1922857
    See related
    Ensembl:ENSMUSG00000037989 AllianceGenome:MGI:1922857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTM15; mKIAA1760; 1810073P09Rik
    Summary
    Predicted to enable potassium channel inhibitor activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Is expressed in central nervous system and neural retina. Orthologous to human WNK2 (WNK lysine deficient protein kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 9.8), cerebellum adult (RPKM 9.2) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wnk2 in Genome Data Viewer
    Location:
    13 A5; 13 25.07 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49189778..49302110, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49036302..49148574, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 120, member A Neighboring gene family with sequence similarity 120A, opposite strand Neighboring gene kinesin family member 11 pseudogene Neighboring gene STARR-seq mESC enhancer starr_34469 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49185630-49185783 Neighboring gene STARR-seq mESC enhancer starr_34472 Neighboring gene predicted gene, 40942 Neighboring gene predicted gene, 40943

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Early epigenetic downregulation of WNK2 kinase during pancreatic ductal adenocarcinoma development. Dutruel C, et al. Oncogene, 2014 Jun 26. PMID 23912455
    2. WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. Rinehart J, et al. J Biol Chem, 2011 Aug 26. PMID 21733846, Free PMC Article
    3. Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed. Izadifar A, et al. Neuron, 2021 Sep 15. PMID 34384519
    4. Genetic mapping of 20 novel expressed sequence tags from midgestation mouse embryos suggests chromosomal clustering. Tchernev VT, et al. Genomics, 1997 Feb 15. PMID 9070936
    5. Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Bettenhausen B, et al. Genomics, 1995 Aug 10. PMID 7490078

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase WNK2
    Names
    protein kinase lysine-deficient 2
    protein kinase with no lysine 2
    NP_001277240.1
    NP_001277242.1
    NP_083637.2
    XP_006517037.1
    XP_006517040.1
    XP_006517042.1
    XP_011242717.1
    XP_011242718.1
    XP_011242719.1
    XP_011242720.1
    XP_011242721.1
    XP_011242722.1
    XP_011242723.1
    XP_011242724.1
    XP_011242725.1
    XP_011242726.1
    XP_011242727.1
    XP_011242728.1
    XP_011242729.1
    XP_017171115.1
    XP_017171116.1
    XP_030103304.1
    XP_030103305.1
    XP_030103306.1
    XP_030103307.1
    XP_030103308.1
    XP_030103309.1
    XP_030103310.1
    XP_036014099.1
    XP_036014100.1
    XP_036014101.1
    XP_036014102.1
    XP_036014103.1
    XP_036014104.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290311.1 → NP_001277240.1  serine/threonine-protein kinase WNK2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). This variant is partially supported by the mRNA AK044381.1; the 5' exon structure is inferred based on other transcript alignments at this gene.
      Source sequence(s)
      AA145730, AC160126, AK044381, AK147550, BM941970
      Consensus CDS
      CCDS70454.1
      UniProtKB/TrEMBL
      E0CYT1, E9QM73
      Related
      ENSMUSP00000089212.4, ENSMUST00000091623.10
      Conserved Domains (3) summary
      smart00220
      Location:200 → 453
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 511
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    2. NM_001290313.1 → NP_001277242.1  serine/threonine-protein kinase WNK2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains alternate 3' exon structure, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. This variant is partially supported by the mRNA BC060187.1; the 5' exon structure is inferred based on other transcript alignments at this gene.
      Source sequence(s)
      AC160126, AI464179, AK147550, BC060187, BM941970
      Consensus CDS
      CCDS70455.1
      UniProtKB/TrEMBL
      E0CYT1, E9QMI8
      Related
      ENSMUSP00000105724.3, ENSMUST00000110097.9
      Conserved Domains (3) summary
      smart00220
      Location:200 → 453
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 511
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    3. NM_029361.4 → NP_083637.2  serine/threonine-protein kinase WNK2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons and contains alternate 3' exon structure, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a. This variant is mostly supported by the mRNA AK147550.1, but with correction of a non-consensus splice site.
      Source sequence(s)
      AC160126, AI464179, AK147550, BM941970
      UniProtKB/TrEMBL
      E0CZE3
      Related
      ENSMUSP00000125448.2, ENSMUST00000162581.8
      Conserved Domains (3) summary
      smart00220
      Location:200 → 453
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 511
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      49189778..49302110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158211.1 → XP_036014104.1  serine/threonine-protein kinase WNK2 isoform X31

      UniProtKB/TrEMBL
      E9Q6Q2
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 988
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    2. XM_036158210.1 → XP_036014103.1  serine/threonine-protein kinase WNK2 isoform X29

      UniProtKB/TrEMBL
      E9Q6Q2
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 988
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    3. XM_006516979.3 → XP_006517042.1  serine/threonine-protein kinase WNK2 isoform X28

      UniProtKB/TrEMBL
      E9Q6Q2
      Related
      ENSMUSP00000125539.2, ENSMUST00000162403.8
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 988
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    4. XM_036158208.1 → XP_036014101.1  serine/threonine-protein kinase WNK2 isoform X25

      UniProtKB/TrEMBL
      E0CZE3
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1036
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    5. XM_036158207.1 → XP_036014100.1  serine/threonine-protein kinase WNK2 isoform X24

      UniProtKB/TrEMBL
      E0CZE3
      Conserved Domains (4) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
      NF033761
      Location:1323 → 1479
      gliding_GltJ; adventurous gliding motility protein GltJ

    6. XM_030247449.1 → XP_030103309.1  serine/threonine-protein kinase WNK2 isoform X21

      UniProtKB/TrEMBL
      E0CZE3
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    7. XM_030247447.2 → XP_030103307.1  serine/threonine-protein kinase WNK2 isoform X17

      UniProtKB/TrEMBL
      E9QJQ9
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    8. XM_030247446.1 → XP_030103306.1  serine/threonine-protein kinase WNK2 isoform X14

      UniProtKB/TrEMBL
      E9QJQ9
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    9. XM_036158206.1 → XP_036014099.1  serine/threonine-protein kinase WNK2 isoform X10

      UniProtKB/TrEMBL
      E0CYT1
      Conserved Domains (4) summary
      PHA03247
      Location:700 → 1136
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
      NF033761
      Location:1323 → 1479
      gliding_GltJ; adventurous gliding motility protein GltJ

    10. XM_011244426.2 → XP_011242728.1  serine/threonine-protein kinase WNK2 isoform X23

      UniProtKB/TrEMBL
      E0CZE3
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    11. XM_017315627.2 → XP_017171116.1  serine/threonine-protein kinase WNK2 isoform X20

      UniProtKB/TrEMBL
      E0CZE3
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    12. XM_030247448.1 → XP_030103308.1  serine/threonine-protein kinase WNK2 isoform X18

      UniProtKB/TrEMBL
      E0CZE3
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    13. XM_011244425.2 → XP_011242727.1  serine/threonine-protein kinase WNK2 isoform X16

      UniProtKB/TrEMBL
      E9QJQ9
      Related
      ENSMUSP00000049327.9, ENSMUST00000049265.15
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    14. XM_017315626.2 → XP_017171115.1  serine/threonine-protein kinase WNK2 isoform X13

      UniProtKB/TrEMBL
      E9QJQ9
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    15. XM_030247445.1 → XP_030103305.1  serine/threonine-protein kinase WNK2 isoform X11

      UniProtKB/TrEMBL
      E0CYT1
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    16. XM_011244422.2 → XP_011242724.1  serine/threonine-protein kinase WNK2 isoform X9

      UniProtKB/TrEMBL
      E0CYT1
      Conserved Domains (3) summary
      PHA03247
      Location:700 → 1136
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    17. XM_011244415.4 → XP_011242717.1  serine/threonine-protein kinase WNK2 isoform X1

      UniProtKB/TrEMBL
      E0CYT1
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    18. XM_036158209.1 → XP_036014102.1  serine/threonine-protein kinase WNK2 isoform X26

      UniProtKB/TrEMBL
      E9Q6Q2
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 988
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    19. XM_006516974.4 → XP_006517037.1  serine/threonine-protein kinase WNK2 isoform X19

      UniProtKB/TrEMBL
      E9Q6Q2
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 988
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    20. XM_011244416.3 → XP_011242718.1  serine/threonine-protein kinase WNK2 isoform X2

      UniProtKB/TrEMBL
      E0CYT1
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    21. XM_011244424.3 → XP_011242726.1  serine/threonine-protein kinase WNK2 isoform X15

      UniProtKB/TrEMBL
      E0CZE3
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    22. XM_011244423.3 → XP_011242725.1  serine/threonine-protein kinase WNK2 isoform X12

      UniProtKB/TrEMBL
      E0CZE3
      Conserved Domains (3) summary
      PHA03247
      Location:700 → 1136
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    23. XM_011244421.3 → XP_011242723.1  serine/threonine-protein kinase WNK2 isoform X8

      UniProtKB/TrEMBL
      E0CZE3
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    24. XM_011244420.3 → XP_011242722.1  serine/threonine-protein kinase WNK2 isoform X6

      UniProtKB/TrEMBL
      E9QJQ9
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    25. XM_030247444.1 → XP_030103304.1  serine/threonine-protein kinase WNK2 isoform X7

      UniProtKB/TrEMBL
      E9QJQ9
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    26. XM_011244419.3 → XP_011242721.1  serine/threonine-protein kinase WNK2 isoform X5

      UniProtKB/TrEMBL
      E9QJQ9
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    27. XM_011244417.3 → XP_011242719.1  serine/threonine-protein kinase WNK2 isoform X3

      UniProtKB/TrEMBL
      E0CYT1
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    28. XM_011244418.2 → XP_011242720.1  serine/threonine-protein kinase WNK2 isoform X4

      UniProtKB/TrEMBL
      E0CYT1
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 1068
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    29. XM_011244427.4 → XP_011242729.1  serine/threonine-protein kinase WNK2 isoform X27

      UniProtKB/Swiss-Prot
      Q3UH66, Q3V387, Q6PAN9, Q6ZPI6, Q7TNS1, Q811F2
      Conserved Domains (4) summary
      PHA03247
      Location:464 → 824
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:1025 → 1513
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam12202
      Location:230 → 293
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
      cl21453
      Location:1 → 214
      PKc_like; Protein Kinases, catalytic domain

    30. XM_030247450.2 → XP_030103310.1  serine/threonine-protein kinase WNK2 isoform X30

      UniProtKB/Swiss-Prot
      Q3UH66, Q3V387, Q6PAN9, Q6ZPI6, Q7TNS1, Q811F2
      Conserved Domains (4) summary
      PHA03247
      Location:464 → 792
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:989 → 1477
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam12202
      Location:230 → 293
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
      cl21453
      Location:1 → 214
      PKc_like; Protein Kinases, catalytic domain

    31. XM_006516977.4 → XP_006517040.1  serine/threonine-protein kinase WNK2 isoform X22

      UniProtKB/TrEMBL
      E9Q6Q2, E9QMI9
      Related
      ENSMUSP00000105723.2, ENSMUST00000110096.8
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 988
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UH66.2 GenPept UniProtKB/Swiss-Prot:Q3UH66

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