Dpt dermatopontin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dptprovided by MGI
Official Full Name: dermatopontinprovided by MGI
Primary source: MGI:MGI:1928392
See related: Ensembl:ENSMUSG00000026574 AllianceGenome:MGI:1928392
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Eq1; EQ-1; 1810032B19Rik; 5033416F05Rik
Summary: Predicted to be an extracellular matrix structural constituent. Acts upstream of or within collagen fibril organization and negative regulation of cell population proliferation. Located in collagen-containing extracellular matrix. Is expressed in body wall mesenchyme; germ cell of testis; lip; and musculoskeletal system. Orthologous to human DPT (dermatopontin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 128.3), mammary gland adult (RPKM 87.4) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H2.2; 1 72.12 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (164624232..164651843)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (164796663..164824274)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that DPT fosters adherence but is not required for steady-state hematopoiesis in vivo.
Title: Dermatopontin in Bone Marrow Extracellular Matrix Regulates Adherence but Is Dispensable for Murine Hematopoietic Cell Maintenance.
These findings illustrate a previously uncharacterized role of Dpt in maintaining hematopoietic stem cells ex vivo.
Title: Identification of factors promoting ex vivo maintenance of mouse hematopoietic stem cells by long-term single-cell quantification.
DPT may affect testicular function by affecting the integrity of the bloodtestis barrier.
Title: Increased expression of dermatopontin and its implications for testicular dysfunction in mice.
The DP-4 peptide activated Fn and enhanced cell adhesion activity
Title: Identification of fibronectin binding sites in dermatopontin and their biological function.
The present study provides the first evidence that DPT may be a novel effector of cadmium chloride, highlighting the significant role of DPT in the regulation of claudin-11 expression
Title: Dermatopontin is a novel regulator of the CdCl2-induced decrease in claudin-11 expression.
Aging in the mdx diaphragm seems to be associated with a drastic increase in extracellular matrix proteins incliding dermatopontin.
Title: Proteomics reveals drastic increase of extracellular matrix proteins collagen and dermatopontin in the aged mdx diaphragm model of Duchenne muscular dystrophy.
Cloning of early quiescence-1 gene: Identification of a role in cell quiescence.
Title: Cloning of murine early quiescence-1 gene: the murine counterpart of dermatopontin gene can induce and be induced by cell quiescence.
Targeted disruption of dermatopontin causes abnormal collagen fibrillogenesis
Title: Targeted disruption of dermatopontin causes abnormal collagen fibrillogenesis.
Dermatopontin is an abundant protein in demineralized bone matrix, and it can inhibit the stimulatory effects of BMP-2 on ALP activity in C2C12 cells.
Title: BMP stimulation of alkaline phosphatase activity in pluripotent mouse C2C12 cells is inhibited by dermatopontin, one of the most abundant low molecular weight proteins in demineralized bone matrix.
results suggest that, at the time of implantation, dermatopontin expression in the uterus is primarily regulated spatio-temporally by progesterone via progesterone receptors, and is modulated by the decidual response during implantation
Title: Spatio-temporal expression and regulation of dermatopontin in the early pregnant mouse uterus.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in collagen fibril organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within collagen fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dermatopontin

Names: TRAMP; early quiescence protein-1; tyrosine-rich acidic matrix protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.