Aadat aminoadipate aminotransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aadatprovided by MGI
Official Full Name: aminoadipate aminotransferaseprovided by MGI
Primary source: MGI:MGI:1345167
See related: Ensembl:ENSMUSG00000057228 AllianceGenome:MGI:1345167
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aadt; Kat2; KATII; Kyat2; mKat-2
Summary: Predicted to enable protein homodimerization activity and transaminase activity. Predicted to be involved in 2-oxoglutarate metabolic process; glutamate metabolic process; and kynurenine metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; heart; liver; and metanephros. Orthologous to human AADAT (aminoadipate aminotransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward kidney adult (RPKM 310.8) See more
Orthologs: human all
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Genomic context

Location:: 8 B3.1; 8 30.85 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (60958877..60998711)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (60505843..60545677)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Species-specific neuronal localization of kynurenine aminotransferase-2 in the mouse cerebellum.
Title: Species-specific neuronal localization of kynurenine aminotransferase-2 in the mouse cerebellum.
N-Acetylcysteine Inhibits Kynurenine Aminotransferase II.
Title: N-Acetylcysteine Inhibits Kynurenine Aminotransferase II.
This study demonstrates the presence of kynurenine aminotransferase-2 mRNA and protein throughout the adult C57Bl6 mouse brain
Title: Astrocytic and neuronal localization of kynurenine aminotransferase-2 in the adult mouse brain.
human KAT III/CCBL2 possesses cysteine S-conjugate beta-lyase activity, as does mouse KAT II
Title: Kynurenine aminotransferase III and glutamine transaminase L are identical enzymes that have cysteine S-conjugate β-lyase activity and can transaminate L-selenomethionine.
This study showed that KAT II KO mice show the expected decrease in extracellular kynurenic acid levels, and that this reduction is accompanied by a significant increase in extracellular glutamate.
Title: Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior.
The activity of mouse KAT II was not significantly inhibited by any proteinogenic amino acids at equimolar concentrations and half-life was 27.4 minutes at 65 degree C.
Title: Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases.
Results show that gene targeting of kynurenine aminotransferase II (KAT) in mice leads to early and transitory decreases in brain KAT activity and kynurenic acid levels with commensurate behavioral and neuropathological changes.
Title: Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice.
Alpha7* nAChR and NMDA receptor functions were studied in kynurenine aminotransferase II null mice(mKat-2-/- mice). At 21 postnatal days, mKat-2-/- mice had lower hippocampal kynurenic acid levels and more spontaneous locomotor activity than control mice
Title: Targeted deletion of the kynurenine aminotransferase ii gene reveals a critical role of endogenous kynurenic acid in the regulation of synaptic transmission via alpha7 nicotinic receptors in the hippocampus.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Markers

Kat2 (e-PCR), detects polymorphism
- UniSTS:143650

AI875679 (e-PCR)
- UniSTS:179747

Aadat (e-PCR), detects polymorphism
- UniSTS:256825

AI746383 (e-PCR)
- UniSTS:165580

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2-aminoadipate transaminase activity	ISO Inferred from Sequence Orthology more info
enables 2-aminoadipate transaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycine:2-oxoglutarate aminotransferase activity	ISO Inferred from Sequence Orthology more info
enables glycine:2-oxoglutarate aminotransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables kynurenine-glyoxylate transaminase activity	ISO Inferred from Sequence Orthology more info
enables kynurenine-glyoxylate transaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables kynurenine-oxoglutarate transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kynurenine-oxoglutarate transaminase activity	ISO Inferred from Sequence Orthology more info
enables kynurenine-oxoglutarate transaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables methionine-glyoxylate transaminase activity	ISO Inferred from Sequence Orthology more info
enables methionine-glyoxylate transaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 2-oxoglutarate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in 2-oxoglutarate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-lysine catabolic process to acetyl-CoA via saccharopine	IEA Inferred from Electronic Annotation more info
involved_in alpha-amino acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glutamate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutamate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in kynurenine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in kynurenine metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

Names: 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; KAT/AadAT; alpha-aminoadipate aminotransferase; glycine transaminase AADAT; kynurenine aminotransferase II; kynurenine--glyoxylate transaminase AADAT; kynurenine--oxoglutarate aminotransferase II; kynurenine--oxoglutarate transaminase 2; kynurenine--oxoglutarate transaminase II; methionine--glyoxylate transaminase AADAT

NP_035964.1

EC 2.6.1.39

EC 2.6.1.4

EC 2.6.1.63

EC 2.6.1.7

EC 2.6.1.73

XP_006509460.1

EC 2.6.1.39

EC 2.6.1.4

EC 2.6.1.63

EC 2.6.1.7

EC 2.6.1.73

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011834.2 → NP_035964.1 kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

See identical proteins and their annotated locations for NP_035964.1

Status: VALIDATED

Source sequence(s)

AC137514

Consensus CDS

CCDS22320.1

UniProtKB/Swiss-Prot

Q9WVM8

UniProtKB/TrEMBL

Q3UNS8

Related

ENSMUSP00000078436.3, ENSMUST00000079472.4

Conserved Domains (2) summary

cd00609
Location:34 → 419

AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...

COG0436
Location:12 → 423

AspB; Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

60958877..60998711

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509397.4 → XP_006509460.1 kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform X1

UniProtKB/TrEMBL

Q3UNS8

Conserved Domains (1) summary

COG1167
Location:16 → 412

ARO8; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]