Usp10 ubiquitin specific peptidase 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp10provided by MGI
Official Full Name: ubiquitin specific peptidase 10provided by MGI
Primary source: MGI:MGI:894652
See related: Ensembl:ENSMUSG00000031826 AllianceGenome:MGI:894652
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UBPO; Uchrp; mKIAA0190; 2610014N07Rik
Summary: Predicted to enable several functions, including cysteine-type peptidase activity; p53 binding activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including monoubiquitinated protein deubiquitination; negative regulation of canonical NF-kappaB signal transduction; and negative regulation of stress granule assembly. Predicted to be located in cytoplasm; intermediate filament cytoskeleton; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytosolic ribosome; early endosome; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human USP10 (ubiquitin specific peptidase 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 13.5), limb E14.5 (RPKM 11.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 68.61 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (120637099..120684299)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (119910360..119957560)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP10-mediated deubiquitination of NR3C1 regulates bone homeostasis by controlling CST3 expression.
Title: USP10-mediated deubiquitination of NR3C1 regulates bone homeostasis by controlling CST3 expression.
USP10 alleviates Nepsilon-carboxymethyl-lysine-induced vascular calcification and atherogenesis in diabetes mellitus by promoting AMPK activation.
Title: USP10 alleviates Nε-carboxymethyl-lysine-induced vascular calcification and atherogenesis in diabetes mellitus by promoting AMPK activation.
Epidermal Growth Factor-Like Repeats and Discoidin I-Like Domains 3 Deficiency Attenuates Dilated Cardiomyopathy by Inhibiting Ubiquitin Specific Peptidase 10 Dependent Smad4 Deubiquitination.
Title: Epidermal Growth Factor-Like Repeats and Discoidin I-Like Domains 3 Deficiency Attenuates Dilated Cardiomyopathy by Inhibiting Ubiquitin Specific Peptidase 10 Dependent Smad4 Deubiquitination.
USP10 regulates macrophage inflammation responses via stabilizing NEMO in LPS-induced sepsis.
Title: USP10 regulates macrophage inflammation responses via stabilizing NEMO in LPS-induced sepsis.
USP10 is a potential mediator for vagus nerve stimulation to alleviate neuroinflammation in ischaemic stroke by inhibiting NF-kappaB signalling pathway.
Title: USP10 is a potential mediator for vagus nerve stimulation to alleviate neuroinflammation in ischaemic stroke by inhibiting NF-κB signalling pathway.
Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival.
Title: Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival.
USP10 deubiquitinates Tau, mediating its aggregation.
Title: USP10 deubiquitinates Tau, mediating its aggregation.
Circ-Usp10 promotes microglial activation and induces neuronal death by targeting miRNA-152-5p/CD84.
Title: Circ-Usp10 promotes microglial activation and induces neuronal death by targeting miRNA-152-5p/CD84.
Estrogen prevents cellular senescence and bone loss through Usp10-dependent p53 degradation in osteocytes and osteoblasts: the role of estrogen in bone cell senescence.
Title: Estrogen prevents cellular senescence and bone loss through Usp10-dependent p53 degradation in osteocytes and osteoblasts: the role of estrogen in bone cell senescence.
USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID.
Title: USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130276 (e-PCR)
- UniSTS:213563

Uchrp (e-PCR), detects polymorphism
- UniSTS:144725

NoName (e-PCR)
- UniSTS:225178

HSC0DD052 (e-PCR)
- UniSTS:19905

NoName (e-PCR)
- UniSTS:236023

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular function inhibitor activity	IEA Inferred from Electronic Annotation more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA damage response, signal transduction by p53 class mediator	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response, signal transduction by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoubiquitinated protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in monoubiquitinated protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of stress granule assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress granule assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
involved_in rescue of stalled ribosome	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosolic ribosome	IEA Inferred from Electronic Annotation more info
is_active_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in intermediate filament cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 10

Names: deubiquitinating enzyme 10; ubiquintin c-terminal hydrolase related polypeptide; ubiquitin specific protease 10; ubiquitin thioesterase 10; ubiquitin thiolesterase 10; ubiquitin-specific-processing protease 10

NP_001297559.1

EC 3.4.19.12

NP_033488.1

EC 3.4.19.12

XP_006530908.1

EC 3.4.19.12

XP_006530909.1

EC 3.4.19.12

XP_030099273.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310630.1 → NP_001297559.1 ubiquitin carboxyl-terminal hydrolase 10 isoform 2

See identical proteins and their annotated locations for NP_001297559.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AI846788, AK077453, AK153675, AK165156

Consensus CDS

CCDS80938.1

UniProtKB/Swiss-Prot

P52479, Q3T9L4, Q3TNN5, Q3TZB8, Q3U5E0, Q6ZQG9, Q91VY7

Related

ENSMUSP00000104616.3, ENSMUST00000108988.9

Conserved Domains (2) summary

cd02257
Location:514 → 787

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:408 → 786

UCH; Ubiquitin carboxyl-terminal hydrolase
NM_009462.2 → NP_033488.1 ubiquitin carboxyl-terminal hydrolase 10 isoform 1

See identical proteins and their annotated locations for NP_033488.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AI846788, AK077453, AK153675, DV650223

Consensus CDS

CCDS40495.1

UniProtKB/Swiss-Prot

P52479

Related

ENSMUSP00000123590.2, ENSMUST00000144458.8

Conserved Domains (2) summary

cd02257
Location:515 → 788

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:409 → 787

UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

120637099..120684299

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530845.4 → XP_006530908.1 ubiquitin carboxyl-terminal hydrolase 10 isoform X1

Conserved Domains (2) summary

pfam00443
Location:435 → 812

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam05466
Location:256 → 413

BASP1; Brain acid soluble protein 1 (BASP1 protein)
XM_006530846.4 → XP_006530909.1 ubiquitin carboxyl-terminal hydrolase 10 isoform X2

Conserved Domains (2) summary

pfam00443
Location:434 → 811

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam05466
Location:255 → 412

BASP1; Brain acid soluble protein 1 (BASP1 protein)
XM_030243413.2 → XP_030099273.1 ubiquitin carboxyl-terminal hydrolase 10 isoform X3

Conserved Domains (1) summary

cd02257
Location:82 → 355

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...