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    POP5 RNA-binding protein POP5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851200, updated on 9-Dec-2024

    Summary

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    Official Symbol
    POP5
    Official Full Name
    RNA-binding protein POP5
    Primary source
    SGD:S000000031
    Locus tag
    YAL033W
    See related
    AllianceGenome:SGD:S000000031; FungiDB:YAL033W; VEuPathDB:YAL033W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FUN53
    Summary
    Enables RNA binding activity. Contributes to ribonuclease MRP activity and ribonuclease P activity. Involved in RNA metabolic process. Part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Orthologous to human POP5 (POP5 homolog, ribonuclease P/MRP subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See POP5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (82706..83227)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene MIND complex subunit MTW1 Neighboring gene Fun19p Neighboring gene mRNA splicing protein PRP45 Neighboring gene protein phosphatase regulator GIP4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular analysis of Saccharomyces cerevisiae chromosome I. On the number of genes and the identification of essential genes using temperature-sensitive-lethal mutations. Harris SD, et al. J Mol Biol, 1992 May 5. PMID 1583694
    2. Conserved regions of ribonucleoprotein ribonuclease MRP are involved in interactions with its substrate. Esakova O, et al. Nucleic Acids Res, 2013 Aug. PMID 23700311, Free PMC Article
    3. Interactions of a Pop5/Rpp1 heterodimer with the catalytic domain of RNase MRP. Perederina A, et al. RNA, 2011 Oct. PMID 21878546, Free PMC Article
    4. Comparison of mitochondrial and nucleolar RNase MRP reveals identical RNA components with distinct enzymatic activities and protein components. Lu Q, et al. RNA, 2010 Mar. PMID 20086051, Free PMC Article
    5. In vitro reconstitution and analysis of eukaryotic RNase P RNPs. Perederina A, et al. Nucleic Acids Res, 2018 Jul 27. PMID 29722866, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ribonuclease MRP activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to ribonuclease MRP activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ribonuclease P RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ribonuclease P activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonuclease P activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ribonuclease P activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intronic box C/D snoRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, RNase MRP-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA 5'-leader removal IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of endoribonuclease complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleolar ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleolar ribonuclease P complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonuclease MRP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonuclease MRP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonuclease MRP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of ribonuclease P complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein POP5
    NP_009369.1
    • Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      82706..83227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178178.1 → NP_009369.1  TPA: RNA-binding protein POP5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009369.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPI5, P28005
      UniProtKB/TrEMBL
      A7A0D5, B3LUW7, C7GPK2, C8Z3G8, G2W8J9, N1P7I0
      Conserved Domains (1) summary
      COG1369
      Location:4 → 141
      POP5; RNase P/RNase MRP subunit POP5 [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28005.1

    Gene LinkOut

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