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    SLU7 mRNA splicing protein SLU7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851661, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SLU7
    Official Full Name
    mRNA splicing protein SLU7
    Primary source
    SGD:S000002495
    Locus tag
    YDR088C
    See related
    AllianceGenome:SGD:S000002495; FungiDB:YDR088C; VEuPathDB:YDR088C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SLT17
    Summary
    Contributes to second spliceosomal transesterification activity. Involved in generation of catalytic spliceosome for second transesterification step. Part of U2-type post-spliceosomal complex. Orthologous to human SLU7 (SLU7 homolog, splicing factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SLU7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (618497..619645, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene translocon subunit SSS1 Neighboring gene Rrp1p Neighboring gene tRNA-Arg Neighboring gene Vtc5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An essential splicing factor, SLU7, mediates 3' splice site choice in yeast. Frank D, et al. Genes Dev, 1992 Nov. PMID 1427075
    2. Requirement for SLU7 in yeast pre-mRNA splicing is dictated by the distance between the branchpoint and the 3' splice site. Brys A, et al. RNA, 1996 Jul. PMID 8756413, Free PMC Article
    3. Functional and physical interaction between the yeast splicing factors Slu7 and Prp18. Zhang X, et al. Nucleic Acids Res, 1997 Jun 1. PMID 9153314, Free PMC Article
    4. Mutational analysis identifies two separable roles of the Saccharomyces cerevisiae splicing factor Prp18. Bacíková D, et al. RNA, 2002 Oct. PMID 12403466, Free PMC Article
    5. Splicing factor Prp18p promotes genome-wide fidelity of consensus 3'-splice sites. Roy KR, et al. Nucleic Acids Res, 2023 Dec 11. PMID 37956322, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA 3'-splice site binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to second spliceosomal transesterification activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in generation of catalytic spliceosome for second transesterification step IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type post-spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mRNA splicing protein SLU7
    NP_010373.3
    • RNA splicing factor; required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      618497..619645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180396.3 → NP_010373.3  TPA: mRNA splicing protein SLU7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010373.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS75, P89902, Q02775, Q6Q5U3
      UniProtKB/TrEMBL
      A6ZY54, B3LGI3, B5VFY4, C8Z506
      Conserved Domains (1) summary
      pfam11708
      Location:166 → 347
      Slu7; Pre-mRNA splicing Prp18-interacting factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02775.1

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