CMR1 Cmr1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: CMR1
Official Full Name: Cmr1p
Primary source: SGD:S000002315
Locus tag: YDL156W
See related: AllianceGenome:SGD:S000002315; FungiDB:YDL156W; VEuPathDB:YDL156W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables DNA binding activity. Involved in regulation of DNA damage checkpoint. Located in chromatin; cytoplasm; and nuclear periphery. Orthologous to human WDR76 (WD repeat domain 76). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Cmr1 has a role in regulating Pol II occupancy at transcribed coding sequences.
Title: Recruitment of Saccharomyces cerevisiae Cmr1/Ydl156w to Coding Regions Promotes Transcription Genome Wide.
Yeast gene CMR1/YDL156W is consistently co-expressed with genes participating in DNA-metabolic processes.
Title: Yeast gene CMR1/YDL156W is consistently co-expressed with genes participating in DNA-metabolic processes in a variety of stringent clustering experiments.
Genetic deletion of CMR1 (aka ydl156w) led to a dramatic decrease in the association of H4 with RNA polymerase III proteins, implying a role for Ydl156w in RNA Polymerase III mediated transcription.
Title: Characterization of a highly conserved histone related protein, Ydl156w, and its functional associations using quantitative proteomic analyses.
These results suggest that Cmr1/YDL156W may be involved in DNA-damage responses in yeast.
Title: Saccharomyces cerevisiae Cmr1 protein preferentially binds to UV-damaged DNA in vitro.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA damage checkpoint	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA damage checkpoint	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_010125.1

Nuclear protein with role in transcription, protein quality control; localizes to the intranuclear quality control compartment (INQ) in response to proteasome inhibition or DNA replication stress; INQ likely sequesters proteins involved in DNA metabolism for degradation or re-folding; also localizes to coding regions of transcribed genes; contains three WD domains (WD-40 repeat); human ortholog WDR76 also exhibits perinuclear localization under similar stress conditions

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The following sections contain reference sequences that belong to a specific genome build. Explain