U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    APT2 adenine phosphoribosyltransferase APT2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852051, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    APT2
    Official Full Name
    adenine phosphoribosyltransferase APT2
    Primary source
    SGD:S000002849
    Locus tag
    YDR441C
    See related
    AllianceGenome:SGD:S000002849; FungiDB:YDR441C; VEuPathDB:YDR441C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable AMP binding activity; adenine binding activity; and adenine phosphoribosyltransferase activity. Predicted to be involved in AMP salvage and adenine salvage. Located in cytoplasm. Human ortholog(s) of this gene implicated in adenine phosphoribosyltransferase deficiency. Orthologous to human APRT (adenine phosphoribosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See APT2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1344517..1345062, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Lrs4p Neighboring gene histone methyltransferase DOT1 Neighboring gene Ssn2p Neighboring gene putative hydrolase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A Saccharomyces cerevisiae gene encoding a potential adenine phosphoribosyltransferase. Yuryev A, et al. Yeast, 1994 May. PMID 7941749
    2. APT1, but not APT2, codes for a functional adenine phosphoribosyltransferase in Saccharomyces cerevisiae. Alfonzo JD, et al. J Bacteriol, 1999 Jan. PMID 9864350, Free PMC Article
    3. Combining multisource information through functional-annotation-based weighting: gene function prediction in yeast. Ray SS, et al. IEEE Trans Biomed Eng, 2009 Feb. PMID 19272921
    4. Gene dosage effects in yeast support broader roles for the LOG1, HAM1 and DUT1 genes in detoxification of nucleotide analogues. Carlsson M, et al. PLoS One, 2018. PMID 29738539, Free PMC Article
    5. Genetic investigation of purine nucleotide imbalance in Saccharomyces cerevisiae. Saint-Marc C, et al. Curr Genet, 2020 Dec. PMID 32780163

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables AMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in AMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenine salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    adenine phosphoribosyltransferase APT2
    NP_010729.3
    • Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1344517..1345062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180749.3 → NP_010729.3  TPA: adenine phosphoribosyltransferase APT2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010729.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P36973, Q04090
      UniProtKB/TrEMBL
      B3LFL8, B5VGX2, C7GTP4, G2WBH4, N1PAK2
      Conserved Domains (1) summary
      cl00309
      Location:11 → 180
      PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36973.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools