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    BST1 Bst1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850519, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BST1
    Official Full Name
    Bst1p
    Primary source
    SGD:S000001869
    Locus tag
    YFL025C
    See related
    AllianceGenome:SGD:S000001869; FungiDB:YFL025C; VEuPathDB:YFL025C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PER17
    Summary
    Enables phosphatidylinositol deacylase activity. Involved in several processes, including ERAD pathway; GPI anchor metabolic process; and protein retention in ER lumen. Located in endoplasmic reticulum. Orthologous to human PGAP1 (post-GPI attachment to proteins inositol deacylase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BST1 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (84145..87234, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein GYP8 Neighboring gene alpha-factor pheromone receptor STE2 Neighboring gene Epl1p Neighboring gene Bud27p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding. Vashist S, et al. J Cell Biol, 2001 Oct 29. PMID 11673477, Free PMC Article
    2. Null mutation in PGAP1 impairing Gpi-anchor maturation in patients with intellectual disability and encephalopathy. Murakami Y, et al. PLoS Genet, 2014 May. PMID 24784135, Free PMC Article
    3. Inositol deacylation by Bst1p is required for the quality control of glycosylphosphatidylinositol-anchored proteins. Fujita M, et al. Mol Biol Cell, 2006 Feb. PMID 16319176, Free PMC Article
    4. Genes that control the fidelity of endoplasmic reticulum to Golgi transport identified as suppressors of vesicle budding mutations. Elrod-Erickson MJ, et al. Mol Biol Cell, 1996 Jul. PMID 8862519, Free PMC Article
    5. Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p. Tanaka S, et al. J Biol Chem, 2004 Apr 2. PMID 14734546

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol deacylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol deacylase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein retention in ER lumen IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-lipid complex remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bst1p
    NP_116628.1
    • GPI inositol deacylase of the endoplasmic reticulum (ER); negatively regulates COPII vesicle formation; prevents production of vesicles with defective subunits; required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; functional ortholog of human PGAP1, mutation of which is associated with intellectual disability and encephalopathy

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      84145..87234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179941.1 → NP_116628.1  TPA: Bst1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116628.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTK5, P43571
      UniProtKB/TrEMBL
      C7GY86, G2WDB6, N1PA20
      Conserved Domains (1) summary
      pfam07819
      Location:132 → 369
      PGAP1; PGAP1-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43571.1

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