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    FCY22 purine-cytosine permease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856789, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FCY22
    Official Full Name
    purine-cytosine permease
    Primary source
    SGD:S000002958
    Locus tag
    YER060W-A
    See related
    AllianceGenome:SGD:S000002958; FungiDB:YER060W-A; VEuPathDB:YER060W-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables nucleobase transmembrane transporter activity. Involved in cytosine transport. Located in cell periphery and fungal-type vacuole. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FCY22 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (276572..278164)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Pcl6p Neighboring gene purine-cytosine permease Neighboring gene fatty acid synthase CEM1 Neighboring gene glycerol-1-phosphatase GPP2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New plasmid system to select for Saccharomyces cerevisiae purine-cytosine permease affinity mutants. Wagner R, et al. J Bacteriol, 2001 Jul. PMID 11418581, Free PMC Article
    2. Various cytosine/adenine permease homologues are involved in the toxicity of 5-fluorocytosine in Saccharomyces cerevisiae. Paluszynski JP, et al. Yeast, 2006 Jul 15. PMID 16845689
    3. Identification of genes affecting hydrogen sulfide formation in Saccharomyces cerevisiae. Linderholm AL, et al. Appl Environ Microbiol, 2008 Mar. PMID 18192430, Free PMC Article
    4. PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response. Ferrari E, et al. Mol Cell, 2017 Jul 20. PMID 28648781, Free PMC Article
    5. Loss of Cardiolipin Leads to Perturbation of Acetyl-CoA Synthesis. Raja V, et al. J Biol Chem, 2017 Jan 20. PMID 27941023, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nucleobase transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleobase transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytosine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytosine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in purine-containing compound transmembrane transport ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    purine-cytosine permease
    NP_010982.1
    • Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      276572..278164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180858.1 → NP_010982.1  TPA: purine-cytosine permease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010982.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLW5, Q12119
      UniProtKB/TrEMBL
      N1P3E2
      Conserved Domains (1) summary
      COG1457
      Location:62 → 530
      CodB; Purine-cytosine permease or related protein [Nucleotide transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12119.1

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