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    CUL3 cullin CUL3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852886, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CUL3
    Official Full Name
    cullin CUL3
    Primary source
    SGD:S000003235
    Locus tag
    YGR003W
    See related
    AllianceGenome:SGD:S000003235; FungiDB:YGR003W; VEuPathDB:YGR003W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin-protein transferase activity. Involved in ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Part of Cul3-RING ubiquitin ligase complex. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism and syndromic X-linked intellectual disability Cabezas type. Orthologous to several human genes including CUL3 (cullin 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CUL3 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (500132..502366)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene protein-lysine N-methyltransferase Neighboring gene Swc4p Neighboring gene peroxisome biogenesis protein Neighboring gene transcription factor IIF subunit TFG2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the yeast Rad7-Elc1 complex and assembly of the Rad7-Rad16-Elc1-Cul3 complex. Liu L, et al. DNA Repair (Amst), 2019 May. PMID 30840920
    2. ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells. Ribar B, et al. Mol Cell Biol, 2007 Apr. PMID 17296727, Free PMC Article
    3. Saccharomyces cerevisiae ubiquitin-like protein Rub1 conjugates to cullin proteins Rtt101 and Cul3 in vivo. Laplaza JM, et al. Biochem J, 2004 Jan 15. PMID 14519104, Free PMC Article
    4. A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression. Michel JJ, et al. J Biol Chem, 2003 Jun 20. PMID 12676951
    5. Distinct functions of the ubiquitin-proteasome pathway influence nucleotide excision repair. Gillette TG, et al. EMBO J, 2006 Jun 7. PMID 16675952, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-137 was able to promote sensitivity of PC cells to chemotherapy via inhibition of autophagy mediated by ATG5
      Title: Crystal structure of the yeast Rad7-Elc1 complex and assembly of the Rad7-Rad16-Elc1-Cul3 complex.
    2. Elongin A (Ela1) and cullin 3 (Cul3) are required for Pol II polyubiquitylation and degradation in yeast cells and an E3 comprised of elongin C (Elc1), Ela1, Cul3, and the RING finger protein Roc1 (Rbx1) mediates this process.
      Title: ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Cul3-RING ubiquitin ligase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of cullin-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    cullin CUL3
    NP_011517.1
    • Ubiquitin-protein ligase; forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      500132..502366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181132.1 → NP_011517.1  TPA: cullin CUL3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011517.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUE0, P53202
      UniProtKB/TrEMBL
      G2WE96, N1P3R5
      Conserved Domains (1) summary
      COG5647
      Location:1 → 744
      COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53202.1

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