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    GPI10 putative glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852735, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GPI10
    Official Full Name
    putative glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase
    Primary source
    SGD:S000003110
    Locus tag
    YGL142C
    See related
    AllianceGenome:SGD:S000003110; FungiDB:YGL142C; VEuPathDB:YGL142C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alpha-1,2-mannosyltransferase activity. Involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Used to study sleeping sickness. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 80. Orthologous to human PIGB (phosphatidylinositol glycan anchor biosynthesis class B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GPI10 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (236269..238119, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene putative lipase ROG1 Neighboring gene Mrf1p Neighboring gene ubiquitin-ubiquitin ligase HUL5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae GPI10, the functional homologue of human PIG-B, is required for glycosylphosphatidylinositol-anchor synthesis. Sütterlin C, et al. Biochem J, 1998 May 15. PMID 9576863, Free PMC Article
    2. GPI anchor biosynthesis in yeast: phosphoethanolamine is attached to the alpha1,4-linked mannose of the complete precursor glycophospholipid. Canivenc-Gansel E, et al. Glycobiology, 1998 Aug. PMID 9639537
    3. VCP/Cdc48 rescues the growth defect of a GPI10 mutant in yeast. Ohnuma Y, et al. FEBS Lett, 2015 Feb 27. PMID 25625920
    4. In vivo characterization of the GPI assembly defect in yeast mcd4-174 mutants and bypass of the Mcd4p-dependent step in mcd4Delta cells. Wiedman JM, et al. FEMS Yeast Res, 2007 Jan. PMID 17311586
    5. Phosphatidylethanolamine is the donor of the phosphorylethanolamine linked to the alpha1,4-linked mannose of yeast GPI structures. Imhof I, et al. Glycobiology, 2000 Dec. PMID 11159918

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,2-mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate derivative biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase
    NP_011373.1
    • Integral membrane protein involved in GPI anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the glycosylphosphatidylinositol (GPI) core structure; human PIG-Bp is a functional homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      236269..238119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181007.1 → NP_011373.1  TPA: putative glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011373.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU07, P30777
      UniProtKB/TrEMBL
      B5VII8, C8Z8A8
      Conserved Domains (1) summary
      pfam03901
      Location:16 → 484
      Glyco_transf_22; Alg9-like mannosyltransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30777.2

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