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    RNA15 Rna15p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852838, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RNA15
    Official Full Name
    Rna15p
    Primary source
    SGD:S000003012
    Locus tag
    YGL044C
    See related
    AllianceGenome:SGD:S000003012; FungiDB:YGL044C; VEuPathDB:YGL044C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity. Involved in mRNA processing. Part of mRNA cleavage stimulating factor complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human CSTF2 (cleavage stimulation factor subunit 2) and CSTF2T (cleavage stimulation factor subunit 2 tau variant). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RNA15 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (416146..417036, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-Val Neighboring gene Rim8p Neighboring gene transcription elongation factor DST1 Neighboring gene uncharacterized protein Neighboring gene Dpc13p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the Rna15 RRM-RNA complex reveals the molecular basis of GU specificity in transcriptional 3'-end processing factors. Pancevac C, et al. Nucleic Acids Res, 2010 May. PMID 20097654, Free PMC Article
    2. Multipurpose vectors designed for the fast generation of N- or C-terminal epitope-tagged proteins. Cullin C, et al. Yeast, 1994 Jan. PMID 7515538
    3. The C-terminal domains of vertebrate CstF-64 and its yeast orthologue Rna15 form a new structure critical for mRNA 3'-end processing. Qu X, et al. J Biol Chem, 2007 Jan 19. PMID 17116658
    4. Cellular localization of RNA14p and RNA15p, two yeast proteins involved in mRNA stability. Bonneaud N, et al. J Cell Sci, 1994 Apr. PMID 7520044
    5. Crystal structure of the Rna14-Rna15 complex. Paulson AR, et al. RNA, 2012 Jun. PMID 22513198, Free PMC Article

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CF IA is reconstituted from Rna14, Rna15, Pcf11, and Clp1 proteins in 2:2:1:1 stoichiometry.
      Title: Reconstitution of CF IA from overexpressed subunits reveals stoichiometry and provides insights into molecular topology.
    2. Data show that mutation of residues within the minimal heterodimer region inhibit association of full-length Rna14p and Rna15p.
      Title: Locked tether formation by cooperative folding of Rna14p monkeytail and Rna15p hinge domains in the yeast CF IA complex.
    3. The NMR structure of the 34 -kDa ternary complex of the RNA recognition motif (RRM) domains of Hrp1 and Rna15 bound to two neighboring elements upstream of the cleavage site
      Title: Novel protein-protein contacts facilitate mRNA 3'-processing signal recognition by Rna15 and Hrp1.
    4. after inhibition of CFIA components Rna14p and Rna15p, the snoRNP proteins Nop1p, Nop58p, and Gar1p delocalize from the nucleolus and accumulate in discrete nucleoplasmic foci
      Title: Inactivation of cleavage factor I components Rna14p and Rna15p induces sequestration of small nucleolar ribonucleoproteins at discrete sites in the nucleus.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage stimulating factor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rna15p
    NP_011471.1
    • Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping and maintenance of genome stability

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      416146..417036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180909.1 → NP_011471.1  TPA: Rna15p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011471.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU95, P25299
      UniProtKB/TrEMBL
      A6ZUV2, B3LIQ4, C7GS23, C8Z8J9, G2WE51, N1P1Y1
      Conserved Domains (2) summary
      pfam14304
      Location:255 → 291
      CSTF_C; Transcription termination and cleavage factor C-terminal
      cd12398
      Location:18 → 94
      RRM_CSTF2_RNA15_like; RNA recognition motif (RRM) found in cleavage stimulation factor subunit 2 (CSTF2), yeast ortholog mRNA 3'-end-processing protein RNA15 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25299.1

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