U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GUP1 O-acyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852796, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GUP1
    Official Full Name
    O-acyltransferase
    Primary source
    SGD:S000003052
    Locus tag
    YGL084C
    See related
    AllianceGenome:SGD:S000003052; FungiDB:YGL084C; VEuPathDB:YGL084C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables O-acyltransferase activity. Involved in GPI anchor biosynthetic process; glycerol catabolic process; and glycerol transmembrane transport. Located in endoplasmic reticulum and plasma membrane. Human ortholog(s) of this gene implicated in chondrodysplasia-pseudohermaphroditism syndrome. Orthologous to several human genes including HHAT (hedgehog acyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GUP1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (350616..352298, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene coiled-coil domain-containing protein MAD1 Neighboring gene Lcl3p Neighboring gene Scy1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The yeast O-acyltransferase Gup1p interferes in lipid metabolism with direct consequences on the sphingolipid-sterol-ordered domains integrity/assembly. Ferreira C, et al. Biochim Biophys Acta, 2008 Nov. PMID 18786505
    2. Quantitative differential proteomics of yeast extracellular matrix: there is more to it than meets the eye. Faria-Oliveira F, et al. BMC Microbiol, 2015 Nov 25. PMID 26608260, Free PMC Article
    3. Subcellular localization and functional expression of the glycerol uptake protein 1 (GUP1) of Saccharomyces cerevisiae tagged with green fluorescent protein. Bleve G, et al. Biochem J, 2005 Aug 15. PMID 15813700, Free PMC Article
    4. Programmed cell death in Saccharomyces cerevisiae is hampered by the deletion of GUP1 gene. Tulha J, et al. BMC Microbiol, 2012 May 22. PMID 22617017, Free PMC Article
    5. GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor. Bosson R, et al. Mol Biol Cell, 2006 Jun. PMID 16597698, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. As a first step toward identifying the actual molecular/enzymatic function of Gup1, this work identified by co-immunoprecipitation the yeast mitochondria membrane VDAC1/Por1 as a physical partner of Gup1.
      Title: Saccharomyces cerevisiae mitochondrial Por1/yVDAC1 (voltage-dependent anion channel 1) interacts physically with the MBOAT O-acyltransferase Gup1/HHATL in the control of cell wall integrity and programmed cell death.
    2. Cells lacking GUP1 are not capable of undergoing apoptosis but instead appear to be experiencing a necrotic cell death process, upon both chronological aging and acetic acid induction.
      Title: Programmed cell death in Saccharomyces cerevisiae is hampered by the deletion of GUP1 gene.
    3. Gup1p is involved in lipid metabolism and shows the direct consequences of its absence on the plasma membrane sphingolipid-sterol-ordered domains integrity/assembly.
      Title: The yeast O-acyltransferase Gup1p interferes in lipid metabolism with direct consequences on the sphingolipid-sterol-ordered domains integrity/assembly.
    4. GUP1 function depends on the active site histidine and is highly conserved among fungi and protozoa.
      Title: GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables O-acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerol catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerol transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    O-acyltransferase
    NP_011431.1
    • Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; role in misfolded protein quality control; proposed to be involved in glycerol transport; homolog of the mammalian Hedgehog pathway modulator HHATL; GUP1 has a paralog, GUP2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      350616..352298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180949.1 → NP_011431.1  TPA: O-acyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011431.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU60, P53154
      UniProtKB/TrEMBL
      A6ZU95, B3LHF0, B5VIP0, C7GW32, C8Z8G4
      Conserved Domains (1) summary
      COG1696
      Location:39 → 560
      DltB; D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily [Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53154.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools