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    SCL1 proteasome core particle subunit alpha 1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852873, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SCL1
    Official Full Name
    proteasome core particle subunit alpha 1
    Primary source
    SGD:S000002979
    Locus tag
    YGL011C
    See related
    AllianceGenome:SGD:S000002979; FungiDB:YGL011C; VEuPathDB:YGL011C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PRC2
    Summary
    Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in mitochondrion. Part of proteasome core complex, alpha-subunit complex. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PSMA6 (proteasome 20S subunit alpha 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SCL1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (474489..475247, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene drug-responsive transcription factor PDR1 Neighboring gene delta(24(24(1)))-sterol reductase Neighboring gene Mpo1p Neighboring gene 3-isopropylmalate dehydratase LEU1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a Saccharomyces cerevisiae mutant with pseudohyphae and cloning of a gene complementing the mutation. Maneesri J, et al. Biosci Biotechnol Biochem, 2003 Mar. PMID 12723598
    2. Proteasomes are essential for yeast proliferation. cDNA cloning and gene disruption of two major subunits. Fujiwara T, et al. J Biol Chem, 1990 Sep 25. PMID 1697860
    3. Molecular cloning of the yeast proteasome PRS2 gene identical to the suppressor gene scl1+. Lee DH, et al. Biochem Int, 1991 Mar. PMID 1872882
    4. The suppressor gene scl1+ of Saccharomyces cerevisiae is essential for growth. Balzi E, et al. Gene, 1989 Nov 30. PMID 2684789
    5. Molecular cloning and functional analysis of three subunits of yeast proteasome. Emori Y, et al. Mol Cell Biol, 1991 Jan. PMID 1898763, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasomal ubiquitin-independent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasomal ubiquitin-independent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex, alpha-subunit complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    proteasome core particle subunit alpha 1
    NP_011504.3
    • Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      474489..475247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180876.3 → NP_011504.3  TPA: proteasome core particle subunit alpha 1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011504.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUC6, P15708, P21243
      UniProtKB/TrEMBL
      A6ZUY2, B3LIM6, B5VIV2, C7GK62, C8Z8N2, G2WE82, N1P3C8
      Conserved Domains (1) summary
      cd03754
      Location:12 → 228
      proteasome_alpha_type_6; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21243.1

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