CDH1 Cdh1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CDH1
Official Full Name: Cdh1p
Primary source: SGD:S000002971
Locus tag: YGL003C
See related: AllianceGenome:SGD:S000002971; FungiDB:YGL003C; VEuPathDB:YGL003C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: HCT1
Summary: Enables cyclin binding activity and ubiquitin ligase activator activity. Involved in positive regulation of anaphase-promoting complex-dependent catabolic process and regulation of cell cycle process. Located in cytoplasm and nucleus. Part of anaphase-promoting complex. Used to study disease of cellular proliferation. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 109. Orthologous to human FZR1 (fizzy and cell division cycle 20 related 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CDH1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (492474..494174, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cla4 phosphorylates histone methyltransferase Set1 to prevent its degradation by the APC/C[Cdh1] complex.
Title: Cla4 phosphorylates histone methyltransferase Set1 to prevent its degradation by the APC/C(Cdh1) complex.
The APC/C Activator Cdh1p Plays a Role in Mitochondrial Metabolic Remodelling in Yeast.
Title: The APC/C Activator Cdh1p Plays a Role in Mitochondrial Metabolic Remodelling in Yeast.
Our observations suggest that both APC(Cdh1) and SCF(Cdc4)-dependent proteolysis of Clb6 at the G1/S border are crucial for multiple cell cycle regulated events including proper expression of Clb2, the G1/S and G2/M cell cycle transitions and for proper completion of cell division at mitotic exit.
Title: The anaphase-promoting complex works together with the SCF complex for proteolysis of the S-phase cyclin Clb6 during the transition from G1 to S phase.
results suggest that binding to the D-box receptor may be a shared requirement for recognition and processing of all Cdh1 substrates.
Title: Substrate Recognition by the Cdh1 Destruction Box Receptor Is a General Requirement for APC/CCdh1-mediated Proteolysis.
This study showed that the APC/C(Cdh1) ubiquitinates Ndd1 and mediates its degradation, and that APC/C(Cdh1) activity suppresses accumulation of Ndd1 targets.
Title: Degradation of Ndd1 by APC/C(Cdh1) generates a feed forward loop that times mitotic protein accumulation.
Small N-terminal regions of both Cdc20 (RxxL-type D box) and Cdc5 (KEN motif) were identified as transferable degradation domains (degrons) that mediated efficient targeting by APC/C-Cdh1 (anaphase-promoting complex/cyclosome-Cdh1).
Title: Insights into the cellular mechanism of the yeast ubiquitin ligase APC/C-Cdh1 from the analysis of in vivo degrons.
Cdh1 mediates Cdc20 degradation in metaphase, promoting formation of the APC/C-Cdh1.
Title: Cdh1 is an antagonist of the spindle assembly checkpoint.
the structure of an Acm1-Cdh1 complex
Title: Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex.
chromosome segregation in cdc6 mutant is caused by the deregulation of spindle dynamics induced via a regulatory network involving the ubiquitin-conjugating enzyme Cdc34, microtubule-associated proteins and the anaphase-promoting complex activator Cdh1.
Title: "Reductional anaphase" in replication-defective cells is caused by ubiquitin-conjugating enzyme Cdc34-mediated deregulation of the spindle.
Acm1 is not required to inhibit APC(Cdh1) activity but rather prevents untimely Cdh1-substrate interactions.
Title: Acm1 contributes to nuclear positioning by inhibiting Cdh1-substrate interactions.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables anaphase-promoting complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables anaphase-promoting complex binding	IEA Inferred from Electronic Annotation more info
enables cyclin binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin ligase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin ligase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in deactivation of mitotic spindle assembly checkpoint	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitotic spindle pole body separation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of mitotic spindle pole body separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic actomyosin contractile ring contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of mitotic actomyosin contractile ring contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic metaphase/anaphase transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of anaphase-promoting complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cdh1p

NP_011512.1

Activator of anaphase-promoting complex/cyclosome (APC/C); antagonist of the spindle assembly checkpoint; directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including: Cdc20p, Ase1p, Cin8p, Fin1p and Clb5p; partially active in metaphase, and fully active in anaphase; cell-cycle regulated

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

492474..494174 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180868.1 → NP_011512.1 TPA: Cdh1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011512.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUD5, P53197

UniProtKB/TrEMBL

A6ZUZ0, G2WE91, N1P3R0

Conserved Domains (2) summary

sd00039
Location:305 → 342

7WD40; WD40 repeat [structural motif]

cl29593
Location:269 → 543

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...