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    FOL2 GTP cyclohydrolase I [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853183, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FOL2
    Official Full Name
    GTP cyclohydrolase I
    Primary source
    SGD:S000003499
    Locus tag
    YGR267C
    See related
    AllianceGenome:SGD:S000003499; FungiDB:YGR267C; VEuPathDB:YGR267C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTP cyclohydrolase I activity. Involved in folic acid-containing compound biosynthetic process. Located in nucleus. Used to study dystonia. Human ortholog(s) of this gene implicated in several diseases, including BH4-deficient hyperphenylalaninemia B; diabetic angiopathy; movement disease (multiple); sickle cell anemia; and type 2 diabetes mellitus. Orthologous to human GCH1 (GTP cyclohydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FOL2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1025004..1025735, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene methionine--tRNA ligase MES1 Neighboring gene uncharacterized protein Neighboring gene Hua1p Neighboring gene Yta7p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pterin and folate salvage. Plants and Escherichia coli lack capacity to reduce oxidized pterins. Noiriel A, et al. Plant Physiol, 2007 Mar. PMID 17220358, Free PMC Article
    2. Disruption of the GTP-cyclohydrolase I gene in Saccharomyces cerevisiae. Nardese V, et al. Biochem Biophys Res Commun, 1996 Jan 5. PMID 8573145
    3. Enhancing the natural folate level in wine using bioengineering and stabilization strategies. Liu Y, et al. Food Chem, 2016 Mar 1. PMID 26471523
    4. GTP-cyclohydrolase I gene mutations in patients with autosomal dominant and recessive GTP-CH1 deficiency: identification and functional characterization of four novel mutations. Garavaglia B, et al. J Inherit Metab Dis, 2004. PMID 15303002
    5. Hexavalent chromium stimulation of riboflavin synthesis in flavinogenic yeast. Fedorovych D, et al. Biometals, 2001 Mar. PMID 11368272

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP cyclohydrolase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP cyclohydrolase I activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP cyclohydrolase I activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in folic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in folic acid-containing compound biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pteridine-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrobiopterin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GTP cyclohydrolase I
    NP_011783.1
    • GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis; human homolog GCH1 is implicated in dopa-responsive dystonia (DRD), and can complement yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1025004..1025735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181396.1 → NP_011783.1  TPA: GTP cyclohydrolase I [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011783.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV45, P51601
      UniProtKB/TrEMBL
      A6ZUS4, B3LHX6, B5VJK9, C7GNG6, C8Z9F9, G2WEZ1, N1P4H0
      Conserved Domains (1) summary
      TIGR00063
      Location:61 → 240
      folE; GTP cyclohydrolase I
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51601.1

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