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    PPE1 phosphoprotein phosphatase methylesterase 1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856474, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PPE1
    Official Full Name
    phosphoprotein phosphatase methylesterase 1
    Primary source
    SGD:S000001117
    Locus tag
    YHR075C
    See related
    AllianceGenome:SGD:S000001117; FungiDB:YHR075C; VEuPathDB:YHR075C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein C-terminal methylesterase activity. Involved in C-terminal protein demethylation. Part of mitochondrial small ribosomal subunit. Orthologous to human PPME1 (protein phosphatase methylesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PPE1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (248439..249641, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene oxysterol-binding protein related protein OSH3 Neighboring gene glutamine-dependent NAD(+) synthetase Neighboring gene type 2C protein phosphatase PTC7 Neighboring gene Nmd2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Cloning and functional study of CaPPe1 in Candida albicans by using Saccharomyses cerevisiae model system]. Cao F, et al. Shi Yan Sheng Wu Xue Bao, 2005 Apr. PMID 16011244
    2. A new enrichment approach identifies genes that alter cell cycle progression in Saccharomyces cerevisiae. Bogomolnaya LM, et al. Curr Genet, 2004 Jun. PMID 15022016
    3. Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo. Wu J, et al. EMBO J, 2000 Nov 1. PMID 11060018, Free PMC Article
    4. Generation of active protein phosphatase 2A is coupled to holoenzyme assembly. Hombauer H, et al. PLoS Biol, 2007 Jun. PMID 17550305, Free PMC Article
    5. A genome-wide immunodetection screen in S. cerevisiae uncovers novel genes involved in lysosomal vacuole function and morphology. Ricarte F, et al. PLoS One, 2011. PMID 21912603, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein C-terminal methylesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein C-terminal methylesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein C-terminal methylesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein methylesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in C-terminal protein demethylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mitochondrial small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphoprotein phosphatase methylesterase 1
    NP_011942.1
    • Protein with carboxyl methyl esterase activity; may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      248439..249641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179205.1 → NP_011942.1  TPA: phosphoprotein phosphatase methylesterase 1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011942.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL25, P38796
      UniProtKB/TrEMBL
      A6ZSY2, B3LSJ3, C7GWT7, C8Z9L8, G2WFE8, N1P9D9
      Conserved Domains (1) summary
      pfam00561
      Location:114 → 366
      Abhydrolase_1; alpha/beta hydrolase fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38796.1

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