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    HXT8 hexose transporter HXT8 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853216, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HXT8
    Official Full Name
    hexose transporter HXT8
    Primary source
    SGD:S000003750
    Locus tag
    YJL214W
    See related
    AllianceGenome:SGD:S000003750; FungiDB:YJL214W; VEuPathDB:YJL214W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables D-glucose transmembrane transporter activity; fructose transmembrane transporter activity; and mannose transmembrane transporter activity. Involved in hexose transmembrane transport. Located in cell periphery. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HXT8 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (26887..28596)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Ree1p Neighboring gene oligo-1,6-glucosidase IMA5 Neighboring gene uncharacterized protein Neighboring gene oligopeptide transporter OPT1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Uptake of radiolabeled GlcNAc into Saccharomyces cerevisiae via native hexose transporters and its in vivo incorporation into GPI precursors in cells expressing heterologous GlcNAc kinase. Scarcelli JJ, et al. FEMS Yeast Res, 2012 May. PMID 22151002, Free PMC Article
    2. Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae. Wieczorke R, et al. FEBS Lett, 1999 Dec 31. PMID 10618490
    3. Selection of yeast Saccharomyces cerevisiae promoters available for xylose cultivation and fermentation. Nambu-Nishida Y, et al. J Biosci Bioeng, 2018 Jan. PMID 28869192
    4. Transcriptomic profiling of the Saccharomyces cerevisiae response to quinine reveals a glucose limitation response attributable to drug-induced inhibition of glucose uptake. dos Santos SC, et al. Antimicrob Agents Chemother, 2009 Dec. PMID 19805573, Free PMC Article
    5. Phospholipid transfer protein Sec14 is required for trafficking from endosomes and regulates distinct trans-Golgi export pathways. Curwin AJ, et al. J Biol Chem, 2009 Mar 13. PMID 19129178, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables carbohydrate:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mannose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hexose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mannose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hexose transporter HXT8
    NP_012321.1
    • hypothetical protein with similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      26887..28596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181647.1 → NP_012321.1  TPA: hexose transporter HXT8 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012321.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVY1, P40886
      UniProtKB/TrEMBL
      G2WD81, N1P0E9
      Conserved Domains (1) summary
      pfam00083
      Location:69 → 530
      Sugar_tr; Sugar (and other) transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40886.1

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