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    SED5 t-SNARE syntaxin [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850713, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SED5
    Official Full Name
    t-SNARE syntaxin
    Primary source
    SGD:S000004016
    Locus tag
    YLR026C
    See related
    AllianceGenome:SGD:S000004016; FungiDB:YLR026C; VEuPathDB:YLR026C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables SNAP receptor activity. Involved in Golgi vesicle transport and regulation of inclusion body assembly. Located in cis-Golgi network and membrane. Part of SNARE complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human STX5 (syntaxin 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SED5 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (195450..196472, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene putative ubiquitin-protein ligase UBR2 Neighboring gene ESCRT-III subunit protein SNF7 Neighboring gene aspartate transaminase AAT2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SED5 encodes a 39-kD integral membrane protein required for vesicular transport between the ER and the Golgi complex. Hardwick KG, et al. J Cell Biol, 1992 Nov. PMID 1400588, Free PMC Article
    2. Structural basis for the Golgi membrane recruitment of Sly1p by Sed5p. Bracher A, et al. EMBO J, 2002 Nov 15. PMID 12426383, Free PMC Article
    3. The SM protein Sly1 accelerates assembly of the ER-Golgi SNARE complex. Demircioglu FE, et al. Proc Natl Acad Sci U S A, 2014 Sep 23. PMID 25189771, Free PMC Article
    4. Protein-protein interactions of the yeast Golgi t-SNARE Sed5 protein distinct from its neural plasma membrane cognate syntaxin 1. Kosodo Y, et al. Biochem Biophys Res Commun, 1998 Sep 18. PMID 9753609
    5. SM protein Sly1 and a SNARE Habc domain promote membrane fusion through multiple mechanisms. Duan M, et al. J Cell Biol, 2024 Jun 3. PMID 38478017, Free PMC Article

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Syntaxin 5-dependent phosphorylation of the small heat shock protein Hsp42 and its role in protein quality control.
      Title: Syntaxin 5-dependent phosphorylation of the small heat shock protein Hsp42 and its role in protein quality control.
    2. Our data suggest that Sed5 plays a novel role in autophagy, by regulating the formation of Atg9-containing vesicles in the Golgi apparatus, and the genetic interaction between Sft1/2 and Sed5 is essential for autophagy.
      Title: The Roles of the SNARE Protein Sed5 in Autophagy in Saccharomyces cerevisiae.
    3. Data show that Sed5 binds SLY1 but its stability is not influenced by Sly1 interaction.
      Title: SM-protein-controlled ER-associated degradation discriminates between different SNAREs.
    4. only Sed5p was depleted in vesicles made with Sec24p A-site mutants
      Title: ER-Golgi transport defects are associated with mutations in the Sed5p-binding domain of the COPII coat subunit, Sec24p.
    5. A cycle of Sed5 phosphorylation and dephosphorylation is required for normal t-SNARE function and may choreograph Golgi ordering and dispersal.
      Title: Control of Golgi morphology and function by Sed5 t-SNARE phosphorylation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of inclusion body assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle fusion with Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    t-SNARE syntaxin
    NP_013126.1
    • cis-Golgi t-SNARE syntaxin; required for vesicular transport between the ER and the Golgi complex; binds at least 9 SNARE proteins; plays a role in autophagy by regulating formation of autophagic vesicles in Golgi

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      195450..196472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181913.1 → NP_013126.1  TPA: t-SNARE syntaxin [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013126.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY28, Q01590
      UniProtKB/TrEMBL
      A7A0T2, B3LSZ9, B5VMW4, C7GXH2, C8ZCZ8, N1P027
      Conserved Domains (1) summary
      cd15844
      Location:252 → 324
      SNARE_syntaxin5; SNARE motif of syntaxin 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01590.1

    Gene LinkOut

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