TAL1 sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TAL1
Official Full Name: sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1
Primary source: SGD:S000004346
Locus tag: YLR354C
See related: AllianceGenome:SGD:S000004346; FungiDB:YLR354C; VEuPathDB:YLR354C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables transaldolase activity. Involved in pentose-phosphate shunt. Located in nucleus. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder. Orthologous to human TALDO1 (transaldolase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TAL1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (836350..837357, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The transaldolase TAL1 paralogue NQM1 and the transcription factor VHR1 interact haploproficiently and affect yeast stationary phase survival.
Title: A haploproficient interaction of the transaldolase paralogue NQM1 with the transcription factor VHR1 affects stationary phase survival and oxidative stress resistance.
characterization of NQM1 and TKL2, together with TAL1 and TKL1, regarding their roles in xylose utilization and fermentation
Title: Characterization of non-oxidative transaldolase and transketolase enzymes in the pentose phosphate pathway with regard to xylose utilization by recombinant Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables transaldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transaldolase activity	IDA Inferred from Direct Assay more info	PubMed
enables transaldolase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pentose-phosphate shunt, non-oxidative branch	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1

NP_013458.1

EC 2.2.1.2

Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate; TAL1 has a paralog, NQM1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

836350..837357 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182243.1 → NP_013458.1 TPA: sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013458.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYZ2, P15019

UniProtKB/TrEMBL

A7A1N2, B3RHM3, B5VNP4, C7GRX9, C8ZDW1, G2WJH2, N1NZP0

Conserved Domains (1) summary

TIGR00874
Location:14 → 333

talAB; transaldolase