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    DNF3 aminophospholipid-translocating P4-type ATPase DNF3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855197, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DNF3
    Official Full Name
    aminophospholipid-translocating P4-type ATPase DNF3
    Primary source
    SGD:S000004772
    Locus tag
    YMR162C
    See related
    AllianceGenome:SGD:S000004772; FungiDB:YMR162C; VEuPathDB:YMR162C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphatidylcholine flippase activity; phosphatidylethanolamine flippase activity; and phosphatidylserine flippase activity. Involved in phospholipid translocation. Acts upstream of or within pseudohyphal growth. Located in mating projection tip membrane; trans-Golgi network; and trans-Golgi network transport vesicle. Is active in plasma membrane. Human ortholog(s) of this gene implicated in X-linked congenital hemolytic anemia; autosomal dominant nonsyndromic deafness; and hypomyelinating leukodystrophy 24. Orthologous to human ATP11A (ATPase phospholipid transporting 11A); ATP11B (ATPase phospholipid transporting 11B (putative)); and ATP11C (ATPase phospholipid transporting 11C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DNF3 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (578951..583921, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Cvm1p Neighboring gene type I HSP40 co-chaperone HLJ1 Neighboring gene Inp2p Neighboring gene tRNA-Val

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles. Alder-Baerens N, et al. Mol Biol Cell, 2006 Apr. PMID 16452632, Free PMC Article
    2. Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases. Baldridge RD, et al. Proc Natl Acad Sci U S A, 2012 Feb 7. PMID 22308393, Free PMC Article
    3. The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases. Catty P, et al. FEBS Lett, 1997 Jun 16. PMID 9224683
    4. Pseudohyphal growth in Saccharomyces cerevisiae involves protein kinase-regulated lipid flippases. Frøsig MM, et al. J Cell Sci, 2020 Aug 6. PMID 32661085
    5. An essential subfamily of Drs2p-related P-type ATPases is required for protein trafficking between Golgi complex and endosomal/vacuolar system. Hua Z, et al. Mol Biol Cell, 2002 Sep. PMID 12221123, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine flippase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables phosphatidylcholine flippase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidylcholine floppase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylethanolamine flippase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylethanolamine flippase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables phosphatidylethanolamine flippase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidylserine flippase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylserine flippase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables phosphatidylserine flippase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aminophospholipid translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid translocation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mating projection tip membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aminophospholipid-translocating P4-type ATPase DNF3
    NP_013885.1
    • Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      578951..583921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182666.1 → NP_013885.1  TPA: aminophospholipid-translocating P4-type ATPase DNF3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013885.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZY4, Q12674
      UniProtKB/TrEMBL
      A6ZMM1, C8ZF22, N1P5P4
      Conserved Domains (1) summary
      cd02073
      Location:140 → 1386
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12674.1

    Gene LinkOut

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