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    ERG12 mevalonate kinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855248, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ERG12
    Official Full Name
    mevalonate kinase
    Primary source
    SGD:S000004821
    Locus tag
    YMR208W
    See related
    AllianceGenome:SGD:S000004821; FungiDB:YMR208W; VEuPathDB:YMR208W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RAR1
    Summary
    Enables mevalonate kinase activity. Involved in ergosterol biosynthetic process; farnesyl diphosphate biosynthetic process, mevalonate pathway; and isopentenyl diphosphate biosynthetic process, mevalonate pathway. Located in cytosol and nucleus. Used to study cancer and mevalonic aciduria. Human ortholog(s) of this gene implicated in hyperimmunoglobulinemia D periodic fever syndrome; lipid metabolism disorder; mevalonic aciduria; and porokeratosis. Orthologous to human MVK (mevalonate kinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ERG12 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (684467..685798)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene acetyl-CoA carboxylase HFA1 Neighboring gene uncharacterized protein Neighboring gene putative carboxylic ester hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence of the ERG12 gene of Saccharomyces cerevisiae encoding mevalonate kinase. Oulmouden A, et al. Curr Genet, 1991 Jan. PMID 1645230
    2. Isolation of the ERG12 gene of Saccharomyces cerevisiae encoding mevalonate kinase. Oulmouden A, et al. Gene, 1990 Apr 16. PMID 2161381
    3. Mutations that increase the mitotic stability of minichromosomes in yeast: characterization of RAR1. Kearsey SE, et al. Mol Gen Genet, 1987 Dec. PMID 3323847
    4. Incomplete mitophagy in the mevalonate kinase-deficient Saccharomyces cerevisiae and its relation to the MKD-related autoinflammatory disease in humans. Santos MMS, et al. Biochim Biophys Acta Mol Basis Dis, 2021 Apr 1. PMID 33385519, Free PMC Article
    5. Reduction of background interference in the spectrophotometric assay of mevalonate kinase. Song L. Anal Bioanal Chem, 2006 Mar. PMID 16477420

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Incomplete mitophagy in the mevalonate kinase-deficient Saccharomyces cerevisiae and its relation to the MKD-related autoinflammatory disease in humans.
      Title: Incomplete mitophagy in the mevalonate kinase-deficient Saccharomyces cerevisiae and its relation to the MKD-related autoinflammatory disease in humans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mevalonate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mevalonate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mevalonate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ergosterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ergosterol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    mevalonate kinase
    NP_013935.1
    • Mevalonate kinase; acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate; human MVK functionally complements the lethality of the erg12 null mutation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      684467..685798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182715.1 → NP_013935.1  TPA: mevalonate kinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013935.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W033, P07277
      UniProtKB/TrEMBL
      A6ZMS0, C7GRE3, C8ZF73, G2WKR4, N1P5T7
      Conserved Domains (1) summary
      TIGR00549
      Location:9 → 361
      mevalon_kin; mevalonate kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07277.1

    Gene LinkOut

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