U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    UBP10 ubiquitin-specific protease UBP10 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855535, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    UBP10
    Official Full Name
    ubiquitin-specific protease UBP10
    Primary source
    SGD:S000005130
    Locus tag
    YNL186W
    See related
    AllianceGenome:SGD:S000005130; FungiDB:YNL186W; VEuPathDB:YNL186W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DOT4
    Summary
    Enables cysteine-type deubiquitinase activity. Involved in subtelomeric heterochromatin formation. Located in nuclear replication fork and nucleolus. Orthologous to human USP20 (ubiquitin specific peptidase 20). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See UBP10 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (289498..291876)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Kar1p Neighboring gene Swt21p Neighboring gene mitochondrial 54S ribosomal protein YmL19 Neighboring gene uncharacterized protein Neighboring gene serine/threonine protein kinase NPR1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The deubiquitinating enzyme Dot4p is involved in regulating nutrient uptake. Kahana A. Biochem Biophys Res Commun, 2001 Apr 13. PMID 11352638
    2. Transcriptional profiling of ubp10 null mutant reveals altered subtelomeric gene expression and insurgence of oxidative stress response. Orlandi I, et al. J Biol Chem, 2004 Feb 20. PMID 14623890
    3. Involvement of the yeast metacaspase Yca1 in ubp10Delta-programmed cell death. Bettiga M, et al. FEMS Yeast Res, 2004 Nov. PMID 15489197
    4. Ubp10/Dot4p regulates the persistence of ubiquitinated histone H2B: distinct roles in telomeric silencing and general chromatin. Gardner RG, et al. Mol Cell Biol, 2005 Jul. PMID 15988024, Free PMC Article
    5. The histone deubiquitinating enzyme Ubp10 is involved in rDNA locus control in Saccharomyces cerevisiae by affecting Sir2p association. Calzari L, et al. Genetics, 2006 Dec. PMID 17028327, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A direct interaction between Ubp10 and the Sir2/4 sub-complex facilitates Ubp10 recruitment to chromatin via a co-assembly mechanism.
      Title: Recruitment and allosteric stimulation of a histone-deubiquitinating enzyme during heterochromatin assembly.
    2. show that Ubp10 possesses multiple, distinct binding modules within its IDRs that are necessary and sufficient for directing protein interactions important for Ubp10's known roles in gene silencing and ribosome biogenesis
      Title: A Conserved Deubiquitinating Enzyme Uses Intrinsically Disordered Regions to Scaffold Multiple Protein Interaction Sites.
    3. In this work we present clear evidence indicating that Ubp10 controls PCNA deubiquitylation in S. cerevisiae
      Title: Reversal of PCNA ubiquitylation by Ubp10 in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear replication fork IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ubiquitin-specific protease UBP10
    NP_014213.2
    • Ubiquitin-specific protease, deubiquitinates Ub-protein moieties; interacts with proteins that function in rRNA production and ribosome biogenesis via its intrinsically disordered regions; stabilizes Rpa190p by deubiquitination; controls PCNA deubiquitylation; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p, possibly other transporters; localized to the nucleolus; null mutant phenotypes are functionally complemented by human USP36

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      289498..291876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183024.2 → NP_014213.2  TPA: ubiquitin-specific protease UBP10 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014213.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W101, P53874
      UniProtKB/TrEMBL
      C7GTF8, N1P466
      Conserved Domains (2) summary
      PRK05901
      Location:28 → 221
      PRK05901; RNA polymerase sigma factor; Provisional
      pfam00443
      Location:362 → 730
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53874.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.