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    PFA3 palmitoyltransferase PFA3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855390, updated on 9-Dec-2024

    Summary

    Official Symbol
    PFA3
    Official Full Name
    palmitoyltransferase PFA3
    Primary source
    SGD:S000005270
    Locus tag
    YNL326C
    See related
    AllianceGenome:SGD:S000005270; FungiDB:YNL326C; VEuPathDB:YNL326C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables palmitoyltransferase activity. Involved in protein palmitoylation and vacuole fusion, non-autophagic. Located in fungal-type vacuole membrane. Orthologous to several human genes including ZDHHC2 (zinc finger DHHC-type palmitoyltransferase 2) and ZDHHC20 (zinc finger DHHC-type palmitoyltransferase 20). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See PFA3 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (27337..28347, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Mdj2p Neighboring gene Egt2p Neighboring gene phosphatidylinositol-3,5-bisphosphate 5-phosphatase Neighboring gene Lem3p

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables palmitoyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vacuole fusion, non-autophagic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in fungal-type vacuole IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    palmitoyltransferase PFA3
    NP_014073.1
    • Palmitoyltransferase for Vac8p; required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      27337..28347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183164.1NP_014073.1  TPA: palmitoyltransferase PFA3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014073.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0M1, P42836
      UniProtKB/TrEMBL
      G2WLE5, N1NZX4
      Conserved Domains (1) summary
      COG5273
      Location:1304
      COG5273; Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]