COQ2 4-hydroxybenzoate octaprenyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: COQ2
Official Full Name: 4-hydroxybenzoate octaprenyltransferase
Primary source: SGD:S000005324
Locus tag: YNR041C
See related: AllianceGenome:SGD:S000005324; FungiDB:YNR041C; VEuPathDB:YNR041C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 4-hydroxybenzoate polyprenyltransferase activity. Involved in ubiquinone biosynthetic process. Located in mitochondrial membrane. Used to study coenzyme Q10 deficiency disease; multiple system atrophy; and primary coenzyme Q10 deficiency 1. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 1. Orthologous to human COQ2 (coenzyme Q2, polyprenyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See COQ2 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (700541..701659, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We defined the structure of COQ2 with relevant implications for mutation screening in patients and demonstrated that, contrary to other COQ gene defects such as ADCK3, there is a correlation between COQ2 genotype and patient's phenotype.
Title: The COQ2 genotype predicts the severity of coenzyme Q10 deficiency.
We engineered the subcellular localization of COQ2 in order to clarify whether there is mitochondrial or ER localization of this ubiquinone biosynthetic enzyme.
Title: Engineering of ubiquinone biosynthesis using the yeast coq2 gene confers oxidative stress tolerance in transgenic tobacco.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 4-hydroxybenzoate polyprenyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 4-hydroxybenzoate polyprenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 4-hydroxybenzoate polyprenyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables 4-hydroxybenzoate polyprenyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables polyprenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables prenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in isoprenoid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ubiquinone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 4-hydroxybenzoate octaprenyltransferase

NP_014439.3

EC 2.5.1.39

Para hydroxybenzoate polyprenyl transferase; catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis; human COQ2, mutations in which are implicated in an increased risk of mutiple-system atrophy, can complement a yeast coq2 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

700541..701659 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183218.3 → NP_014439.3 TPA: 4-hydroxybenzoate octaprenyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014439.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1L7, P32378, Q6B1I3

UniProtKB/TrEMBL

B5VR68, C7GLL5, C8ZFS0, N1NWU7

Conserved Domains (1) summary

TIGR01474
Location:80 → 365

ubiA_proteo; 4-hydroxybenzoate polyprenyl transferase, proteobacterial