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    POP3 Pop3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855439, updated on 9-Dec-2024

    Summary

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    Official Symbol
    POP3
    Official Full Name
    Pop3p
    Primary source
    SGD:S000005226
    Locus tag
    YNL282W
    See related
    AllianceGenome:SGD:S000005226; FungiDB:YNL282W; VEuPathDB:YNL282W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to ribonuclease MRP activity and ribonuclease P activity. Involved in RNA metabolic process. Located in cytosol and nucleus. Part of nucleolar ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See POP3 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (107687..108274)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene Wsc2p Neighboring gene Hch1p Neighboring gene delta(14)-sterol reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An active precursor in assembly of yeast nuclear ribonuclease P. Srisawat C, et al. RNA, 2002 Oct. PMID 12403471, Free PMC Article
    2. Pop3p is essential for the activity of the RNase MRP and RNase P ribonucleoproteins in vivo. Dichtl B, et al. EMBO J, 1997 Jan 15. PMID 9029160, Free PMC Article
    3. Proteins Rpr2 and Pop3 increase the activity and thermal stability of yeast RNase P. Perederina A, et al. RNA Biol, 2023 Jan. PMID 37074161, Free PMC Article
    4. In vitro reconstitution and analysis of eukaryotic RNase P RNPs. Perederina A, et al. Nucleic Acids Res, 2018 Jul 27. PMID 29722866, Free PMC Article
    5. Saccharomyces cerevisiae contains an RNase MRP that cleaves at a conserved mitochondrial RNA sequence implicated in replication priming. Stohl LL, et al. Mol Cell Biol, 1992 Jun. PMID 1588958, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proteins Rpr2 and Pop3 increase the activity and thermal stability of yeast RNase P.
      Title: Proteins Rpr2 and Pop3 increase the activity and thermal stability of yeast RNase P.
    2. 3D models of yeast RNase P/MRP proteins Rpp1p and Pop3p.
      Title: 3D models of yeast RNase P/MRP proteins Rpp1p and Pop3p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ribonuclease MRP activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ribonuclease MRP activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to ribonuclease P activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ribonuclease P activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intronic box C/D snoRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intronic box C/D snoRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, RNase MRP-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleolar ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleolar ribonuclease P complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleolar ribonuclease P complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonuclease MRP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonuclease MRP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonuclease MRP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Pop3p
    NP_014117.1
    • Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; increases the activity and thermal stability of the RNase P complex, along with Pop2p; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      107687..108274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183120.1 → NP_014117.1  TPA: Pop3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014117.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0R2, P53833
      UniProtKB/TrEMBL
      A6ZRG3, B3LPC1, B5VQD4, C7GP82, C8ZGN9, G2WLI4, N1NYB7
      Conserved Domains (1) summary
      pfam08228
      Location:14 → 171
      RNase_P_pop3; RNase P subunit Pop3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53833.1

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