GRE2 methylglyoxal reductase (NADPH-dependent) GRE2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GRE2
Official Full Name: methylglyoxal reductase (NADPH-dependent) GRE2
Primary source: SGD:S000005511
Locus tag: YOL151W
See related: AllianceGenome:SGD:S000005511; FungiDB:YOL151W; VEuPathDB:YOL151W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 3-methylbutanal reductase [NAD(P)H] activity and methylglyoxal reductase (NADPH) activity. Involved in ergosterol metabolic process and filamentous growth. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GRE2 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (43694..44722)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gre2 forms a homodimer, each subunit of which contains an N-terminal Rossmann-fold domain and a variable C-terminal domain, which participates in substrate recognition.
Title: Structural insights into the cofactor-assisted substrate recognition of yeast methylglyoxal/isovaleraldehyde reductase Gre2.
In spite of the monomeric nature of Gre2p in solution, packing and self-rotation calculations revealed the existence of two Gre2p protomers per asymmetric unit related by a twofold noncrystallographic axis.
Title: Crystallization and preliminary crystallographic analysis of Gre2p, an NADP(+)-dependent alcohol dehydrogenase from Saccharomyces cerevisiae.
These results indicate a previously unsuspected and novel role for the GRE2 gene product as a suppressor of filamentation by virtue of encoding isovaleraldehyde reductase activity.
Title: A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase.
GRE2 is involved in ergosterol metabolism in Saccharomyces cerevisiae and significantly effects growth.
Title: Involvement of yeast YOL151W/GRE2 in ergosterol metabolism.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3-methylbutanal reductase (NADH) activity	IEA Inferred from Electronic Annotation more info
enables 3-methylbutanal reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables 3-methylbutanal reductase [NAD(P)H] activity	IEA Inferred from Electronic Annotation more info
enables 3-methylbutanal reductase [NAD(P)H] activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables methylglyoxal reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables methylglyoxal reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ergosterol metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ergosterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in filamentous growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: methylglyoxal reductase (NADPH-dependent) GRE2

NP_014490.1

EC 1.1.1.265

EC 1.1.1.283

3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

43694..44722

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183405.1 → NP_014490.1 TPA: methylglyoxal reductase (NADPH-dependent) GRE2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014490.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1R9, Q12068

UniProtKB/TrEMBL

N1NWR8

Conserved Domains (1) summary

cd05227
Location:3 → 318

AR_SDR_e; aldehyde reductase, extended (e) SDRs