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    SWM2 Swm2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855738, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SWM2
    Official Full Name
    Swm2p
    Primary source
    SGD:S000005287
    Locus tag
    YNR004W
    See related
    AllianceGenome:SGD:S000005287; FungiDB:YNR004W; VEuPathDB:YNR004W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in 7-methylguanosine cap hypermethylation and tRNA processing. Located in nucleolus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SWM2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (635943..636383)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative ammonium permease ATO2 Neighboring gene DNA-directed RNA polymerase III subunit C34 Neighboring gene ESCRT-0 subunit protein VPS27 Neighboring gene Atg3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Self-association of Trimethylguanosine Synthase Tgs1 is required for efficient snRNA/snoRNA trimethylation and pre-rRNA processing. Boon KL, et al. Sci Rep, 2015 Jun 15. PMID 26074133, Free PMC Article
    2. Deletion of Swm2p selectively impairs trimethylation of snRNAs by trimethylguanosine synthase (Tgs1p). Boon KL, et al. FEBS Lett, 2010 Aug 4. PMID 20621096
    3. Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways. Heininger AU, et al. RNA Biol, 2016. PMID 26821976, Free PMC Article
    4. Mutational analyses of trimethylguanosine synthase (Tgs1) and Mud2: proteins implicated in pre-mRNA splicing. Chang J, et al. RNA, 2010 May. PMID 20360394, Free PMC Article
    5. Precursors of tRNAs are stabilized by methylguanosine cap structures. Ohira T, et al. Nat Chem Biol, 2016 Aug. PMID 27348091

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Self-association of Tgs1p and its catalytic activity were prerequisite to bypass the requirement for its accessory factor Swm2p for efficient pre-rRNA processing and snRNA trimethylation.
      Title: Self-association of Trimethylguanosine Synthase Tgs1 is required for efficient snRNA/snoRNA trimethylation and pre-rRNA processing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in 7-methylguanosine cap hypermethylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Swm2p
    NP_014401.1
    • Protein with a role in snRNA and snoRNA cap trimethylation; interacts with Tgs1p and shows similar phenotypes; required for trimethylation of the caps of spliceosomal snRNAs and the U3 snoRNA, and for efficient 3' end processing of U3 snoRNA; may act as a specificity factor for Tgs1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      635943..636383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183181.1 → NP_014401.1  TPA: Swm2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014401.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZS79, B3LPN5, C7GLQ0, C8ZFN1, D6W1I0, P40342, Q540B3
      UniProtKB/TrEMBL
      G2WL62, N1NZN5
      Conserved Domains (1) summary
      pfam17083
      Location:14 → 144
      Swm2; Nucleolar protein Swm2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40342.1

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