CRC1 carnitine:acyl carnitine antiporter [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: CRC1
Official Full Name: carnitine:acyl carnitine antiporter
Primary source: SGD:S000005626
Locus tag: YOR100C
See related: AllianceGenome:SGD:S000005626; FungiDB:YOR100C; VEuPathDB:YOR100C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables carnitine:acyl carnitine antiporter activity. Involved in carnitine transmembrane transport and fatty acid metabolic process. Located in mitochondrial inner membrane. Used to study lipid metabolism disorder. Human ortholog(s) of this gene implicated in carnitine-acylcarnitine translocase deficiency. Orthologous to human SLC25A20 (solute carrier family 25 member 20). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables acyl carnitine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables carnitine:acyl carnitine antiporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in acyl carnitine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in carnitine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in carnitine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrial envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_014743.1

Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; human homolog SLC25A20 complements yeast null mutant

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The following sections contain reference sequences that belong to a specific genome build. Explain